MGI phenotypes (allele matching)
B6.129X1-Csrp2tm1Rawe/Ieg
| Status | Available to order |
| EMMA ID | EM:01784 |
| Citation information | RRID:IMSR_EM:01784 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129X1-Csrp2tm1Rawe/Ieg |
| Alternative name | CSRP2 ko |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Csrp2tm1Rawe |
| Gene/Transgene symbol | Csrp2 |
Information from provider
| Provider | Ralf Weiskirchen |
| Provider affiliation | RWTH University Hospital Aachen |
| Genetic information | The Csrp2 gene contains six exons coding for a protein of approximately 21 KDa molecular weight. A neomycin resistance cassette was inserted into exon 4 at nucleotide 7292 via homologous recombination. |
| Phenotypic information | Slight defect of heart function and architecture. In this regard it resembles the Csrp3/MLP knock-out mouse. |
| Breeding history | The strain was backcrossed (N10) and is homozygous for the knock-out construct. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure.;Sagave Julia F, Moser Markus, Ehler Elisabeth, Weiskirchen Sabine, Stoll Doris, Günther Kalle, Büttner Reinhard, Weiskirchen Ralf, ;2008;BMC developmental biology;8;80; 18713466
- The cysteine-rich protein family of highly related LIM domain proteins.;Weiskirchen R, Pino J D, Macalma T, Bister K, Beckerle M C, ;1995;The Journal of biological chemistry;270;28946-54; 7499425