NMRI-Tg(Wap-Tag)8Gmn/Kctt

Status	Available to order
EMMA ID	EM:01785
Citation information	RRID:IMSR_EM:01785 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	NMRI-Tg(Wap-Tag)8Gmn/Kctt
Alternative name	WAP-SVT/t
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Wap-Tag)8Gmn
Gene/Transgene symbol	Tg(Wap-Tag)8Gmn

Information from provider

Provider	Adolf Graessmann
Provider affiliation	Institut für Molekularbiologie und Biochemie
Genetic information	Early SV40 coding region under control of the Wap (whey acidic protein) promoter.
Breeding history	Animals were generated in 1992 and continuously propagated. The transgene is kept at heterozygous state.
References	Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene.;Tzeng Y J, Guhl E, Graessmann M, Graessmann A, ;1993;Oncogene;8;1965-71; 8390039 SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors.;Tzeng Y J, Zimmermann C, Guhl E, Berg B, Avantaggiati M L, Graessmann A, ;1998;Oncogene;16;2103-14; 9572491 The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect.;Goetz F, Tzeng Y J, Guhl E, Merker J, Graessmann M, Graessmann A, ;2001;Oncogene;20;2325-32; 11402328 Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals.;Klein Andreas, Guhl Eva, Zollinger Raphael, Tzeng Yin-Jeh, Wessel Ralf, Hummel Michael, Graessmann Monika, Graessmann Adolf, ;2005;Journal of molecular medicine (Berlin, Germany);83;362-76; 15662539

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Literature references

Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene.;Tzeng Y J, Guhl E, Graessmann M, Graessmann A, ;1993;Oncogene;8;1965-71; 8390039
SV40 T/t-antigen induces premature mammary gland involution by apoptosis and selects for p53 missense mutation in mammary tumors.;Tzeng Y J, Zimmermann C, Guhl E, Berg B, Avantaggiati M L, Graessmann A, ;1998;Oncogene;16;2103-14; 9572491
The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect.;Goetz F, Tzeng Y J, Guhl E, Merker J, Graessmann M, Graessmann A, ;2001;Oncogene;20;2325-32; 11402328
Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals.;Klein Andreas, Guhl Eva, Zollinger Raphael, Tzeng Yin-Jeh, Wessel Ralf, Hummel Michael, Graessmann Monika, Graessmann Adolf, ;2005;Journal of molecular medicine (Berlin, Germany);83;362-76; 15662539

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