FVB.Cg-Tg(Nfh/lacZ)44AApt/Orl

Status	Available to order
EMMA ID	EM:01804
Citation information	RRID:IMSR_EM:01804 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	FVB.Cg-Tg(Nfh/lacZ)44AApt/Orl
Alternative name	NFH-LacZ/FVB
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Nfh/lacZ)44AApt
Gene/Transgene symbol	Tg(Nfh/lacZ)44AApt

Information from provider

Provider	Joel Eyer
Provider affiliation	INSERM, University of Angers
Genetic information	The transgenic construct is a fusion between the mouse neurofilament high subunit (Nefh or Nfh, neurofilament heavy polypeptide) coding sequence and the lacZ reporter gene. This transgene is expressed only in neurons and induce the aggregation of all neurofilaments in the neuronal cell body (Eyer & Peterson, 1994, Neuron, 12:389-405).
Phenotypic information	Aggregation of neurofilaments in the cell body; absence of neurofilaments in axons; electrophysiological abnormalities.
Breeding history	The transgenic mice were backcrossed to FVB for more than 20 generations.
References	Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein.;Eyer J, Peterson A, ;1994;Neuron;12;389-405; 8110465 Pathogenesis of two axonopathies does not require axonal neurofilaments.;Eyer J, Cleveland D W, Wong P C, Peterson A C, ;1998;Nature;391;584-7; 9468135 Accelerated diabetic neuropathy in axons without neurofilaments.;Zochodne Douglas W, Sun Hong-Shuo, Cheng Chu, Eyer Joel, ;2004;Brain : a journal of neurology;127;2193-200; 15289271

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Literature references

Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein.;Eyer J, Peterson A, ;1994;Neuron;12;389-405; 8110465
Pathogenesis of two axonopathies does not require axonal neurofilaments.;Eyer J, Cleveland D W, Wong P C, Peterson A C, ;1998;Nature;391;584-7; 9468135
Accelerated diabetic neuropathy in axons without neurofilaments.;Zochodne Douglas W, Sun Hong-Shuo, Cheng Chu, Eyer Joel, ;2004;Brain : a journal of neurology;127;2193-200; 15289271

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.