MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6;129P2-Abcg1tm1Yah Is(17B1)1Yah/+ +/Orl
| Status | Available to order |
| EMMA ID | EM:01811 |
| Citation information | RRID:IMSR_EM:01811 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Abcg1tm1Yah Is(17B1)1Yah/+ +/Orl |
| Alternative name | Cis (Abcg1< tm1Yah>-U2af1 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Abcg1tm1Yah, Is(17B1)1Yah |
| Gene/Transgene symbol | Abcg1, Is(17B1)1Yah |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models |
| Genetic information | Insertion, by homologous recombination in ES cells using MICER, of a targeting vector containing a loxP site at the Abcg1 locus and of a second vector, on the same homologous chromosome, containing a loxP site at the U2af1 locus. |
| Phenotypic information | No visible phenotype. |
| Breeding history | Generated in 129P2 ES cells. Cells injected in C57BL/6 blastocysts. Backcrossed to C57BL/6 (N3). |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- hypoglycemia / MGI
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- abnormal lung morphology / MGI
- overexpanded pulmonary alveoli / MGI
- hyperactivity / MGI
- abnormal lipid level / MGI
- lung inflammation / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal macrophage morphology / MGI
- abnormal macrophage physiology / MGI
- hepatic steatosis / MGI
- abnormal brown adipose tissue morphology / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- decreased cholesterol efflux / MGI
- increased cholesterol level / MGI
- abnormal phospholipid level / MGI
- increased macrophage derived foam cell number / MGI
- abnormal surfactant secretion / MGI
- increased energy expenditure / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- increased oxygen consumption / MGI
- increased triglyceride level / MGI
- renal/urinary system phenotype / MGI
- increased body temperature / MGI
- decreased susceptibility to diet-induced obesity / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal monocyte differentiation / MGI
- increased dendritic cell number / MGI
- abnormal leukocyte morphology / MGI
- lipidosis / MGI
- abnormal chemokine secretion / MGI
- abnormal fat cell morphology / MGI
Literature references
- A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.;Pereira Patricia Lopes, Magnol Laetitia, Sahún Ignasi, Brault Véronique, Duchon Arnaud, Prandini Paola, Gruart Agnès, Bizot Jean-Charles, Chadefaux-Vekemans Bernadette, Deutsch Samuel, Trovero Fabrice, Delgado-García José María, Antonarakis Stylianos E, Dierssen Mara, Herault Yann, ;2009;Human molecular genetics;18;4756-69; 19783846
- Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.;Duchon Arnaud, Besson Vanessa, Pereira Patricia Lopes, Magnol Laetitia, Hérault Yann, ;2008;Genetics;180;51-9; 18757940