MGI phenotypes (allele matching)
B6;129P2-Del(17Abcg1-Cbs)2Yah/Orl
| Status | Available to order |
| EMMA ID | EM:01812 |
| Citation information | RRID:IMSR_EM:01812 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Del(17Abcg1-Cbs)2Yah/Orl |
| Alternative name | Del(Abcg1-U2af1)Ms2Yah |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Del(17Abcg1-Cbs)2Yah |
| Gene/Transgene symbol | Del(17Abcg1-Cbs)2Yah |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models |
| Genetic information | Deletion of the region between the Abcg1 and U2af1 genes engineered using MICER in HM-1 ES cells. |
| Phenotypic information | Homozygotes: embryonic lethal. Heterozygotes: no major defects. |
| Breeding history | Deletion generated in 129P2 ES cells. Cells injected in C57BL/6 blastocysts. Backcrossed to C57BL/6 (N4). |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Literature references
- A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.;Pereira Patricia Lopes, Magnol Laetitia, Sahún Ignasi, Brault Véronique, Duchon Arnaud, Prandini Paola, Gruart Agnès, Bizot Jean-Charles, Chadefaux-Vekemans Bernadette, Deutsch Samuel, Trovero Fabrice, Delgado-García José María, Antonarakis Stylianos E, Dierssen Mara, Herault Yann, ;2009;Human molecular genetics;18;4756-69; 19783846
- Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310
- Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome.;Marechal Damien, Lopes Pereira Patricia, Duchon Arnaud, Herault Yann, ;2015;PloS one;10;e0115302; 25706610