MGI phenotypes (allele matching)
B6N.129S2-Kif11tm1Much/Orl
| Status | Available to order |
| EMMA ID | EM:01814 |
| Citation information | RRID:IMSR_EM:01814 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.129S2-Kif11tm1Much/Orl |
| Alternative name | B6;129-Knsl1 tmG3m |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Kif11tm1Much |
| Gene/Transgene symbol | Kif11 |
Information from provider
| Provider | Michel Kress |
| Provider affiliation | Institut André Lwoff, CNRS UPR 1983 |
| Genetic information | A 7.8 kb fragment of Knsl1 (Kif11) gene spanning from the PstI site in the intron downsteam the first coding exon to the XbaI site in the third coding exon, was deleted and replaced by an IRES-beta-geo-cassette, which has an upstream splicing acceptor, an internal ribosome entry site and a 3' polyadenylation signal. |
| Phenotypic information | The Eg5 product of Knsl1 (Kif11) gene is a major kinesin motor protein involved in mitosis, and its absence leads to prometaphase block. Homozygous null mutants are not viable. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Microcephaly-lymphedema-chorioretinopathy syndrome / Orphanet_2526
MGI phenotypes (gene matching)
- decreased embryo size / MGI
- failure of embryo implantation / MGI
- embryonic growth arrest / MGI
- failure of blastocyst to hatch from the zona pellucida / MGI
- embryonic lethality before implantation / MGI
- abnormal preimplantation embryo development / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- failure of morula compaction / MGI
Literature references
- Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.;Blangy A, Lane H A, d'Hérin P, Harper M, Kress M, Nigg E A, ;1995;Cell;83;1159-69; 8548803
- The Knsl1 gene encoding the kinesin-related protein MmEg5 maps to mouse chromosome 19 and a related pseudogene maps to mouse chromosome 6.;Chauvière M, Poirier C, d'Hérin P, Kress M, ;2000;Cytogenetics and cell genetics;89;16-7; 10894929
- Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality.;Chauvière Muriel, Kress Chantal, Kress Michel, ;2008;Biochemical and biophysical research communications;372;513-9; 18474226