B6.D2(Cg)-Cacna2d2^ent/Ieg

Status	Available to order
EMMA ID	EM:01818
Citation information	RRID:IMSR_EM:01818 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.D2(Cg)-Cacna2d2^ent/Ieg
Alternative name	Cacna2d2 entla
Strain type	Spontaneous
Allele/Transgene symbol	Cacna2d2^ent
Gene/Transgene symbol	Cacna2d2

Information from provider

Provider	Cord-Michael Becker
Provider affiliation	Department of Molecular Cell Biology - Max-Planck-Institute of Biochemistry
Genetic information	Duplication of exon 3 of Cacna2d2.
Phenotypic information	Absence epilepsy, paroxysmal dyskinesia, ataxia, female infertility due to dysmorphic uterus, male fertility reduced (probably due to motor deficit).
Breeding history	N15 C57BL/6J.
References	entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.;Brill Julia, Klocke Rainer, Paul Dieter, Boison Detlev, Gouder Nicolette, Klugbauer Norbert, Hofmann Franz, Becker Cord-Michael, Becker Kristina, ;2004;The Journal of biological chemistry;279;7322-30; 14660671

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)

abnormal kidney morphology / IMPC
abnormal testis morphology / IMPC
small seminal vesicle / IMPC
abnormal spleen morphology / IMPC
small kidney / IMPC
tremors / IMPC
abnormal skin morphology / IMPC
small heart / IMPC
enlarged spleen / IMPC
increased lean body mass / IMPC
preweaning lethality, incomplete penetrance / IMPC
no spontaneous movement / IMPC
persistence of hyaloid vascular system / IMPC
enlarged kidney / IMPC
abnormal gait / IMPC
abnormal vitreous body morphology / IMPC
cataract / IMPC
abnormal placenta morphology / IMPC
female infertility / IMPC
increased spleen weight / IMPC
abnormal heart morphology / IMPC
enlarged testis / IMPC
decreased total body fat amount / IMPC
abnormal seminal vesicle morphology / IMPC
small spleen / IMPC

MGI phenotypes (allele matching)

abnormal uterus morphology / MGI
decreased body weight / MGI
decreased body size / MGI
abnormal locomotor behavior / MGI
ataxia / MGI
abnormal gait / MGI
female infertility / MGI
seizures / MGI
abnormal sexual interaction / MGI
nervous system phenotype / MGI
abnormal neuron physiology / MGI
abnormal brain wave pattern / MGI
behavioral arrest / MGI
postnatal lethality, incomplete penetrance / MGI

MGI phenotypes (gene matching)

myoclonus / MGI
abnormal pituitary gland morphology / MGI
tremors / MGI
hindlimb paralysis / MGI
abnormal hindbrain morphology / MGI
abnormal medulla oblongata morphology / MGI
abnormal cerebellum morphology / MGI
small cerebellum / MGI
cerebellum vermis hypoplasia / MGI
Purkinje cell degeneration / MGI
abnormal Purkinje cell morphology / MGI
decreased Purkinje cell number / MGI
abnormal myelination / MGI
abnormal motor neuron morphology / MGI
abnormal CNS glial cell morphology / MGI
abnormal spinal cord morphology / MGI
decreased spinal cord size / MGI
abnormal neuromuscular synapse morphology / MGI
abnormal spinal nerve morphology / MGI
abnormal uterus morphology / MGI
absent corpus luteum / MGI
decreased body weight / MGI
decreased body size / MGI
abnormal stationary movement / MGI
abnormal locomotor behavior / MGI
ataxia / MGI
impaired coordination / MGI
abnormal gait / MGI
dehydration / MGI
abnormal eating behavior / MGI
limb grasping / MGI
abnormal motor coordination/balance / MGI
abnormal heart rate / MGI
postnatal growth retardation / MGI
thymus hypoplasia / MGI
abnormal thymus involution / MGI
rhinitis / MGI
reduced fertility / MGI
reduced male fertility / MGI
reduced female fertility / MGI
female infertility / MGI
seizures / MGI
abnormal motor capabilities/coordination/movement / MGI
premature death / MGI
no abnormal phenotype detected / MGI
decreased brain weight / MGI
abnormal CNS synaptic transmission / MGI
abnormal nervous system electrophysiology / MGI
abnormal sexual interaction / MGI
tonic seizures / MGI
abnormal neuron morphology / MGI
increased susceptibility to pharmacologically induced seizures / MGI
absence seizures / MGI
axonal dystrophy / MGI
abnormal involuntary movement / MGI
nervous system phenotype / MGI
abnormal glial cell physiology / MGI
decreased neurotransmitter release / MGI
abnormal ventral spinal root morphology / MGI
abnormal dorsal spinal root morphology / MGI
abnormal vertebral column morphology / MGI
short vertebral body / MGI
abnormal neuron physiology / MGI
abnormal miniature endplate potential / MGI
abnormal brain wave pattern / MGI
lethargy / MGI
decreased heart rate / MGI
endocrine/exocrine gland phenotype / MGI
reproductive system phenotype / MGI
abnormal axon morphology / MGI
abnormal enzyme/coenzyme activity / MGI
abnormal hindbrain development / MGI
abnormal spinal cord white matter morphology / MGI
behavioral arrest / MGI
absent lactotrophs / MGI
decreased survivor rate / MGI
abnormal spike wave discharge / MGI
induced hyperactivity / MGI
decreased neuron number / MGI
abnormal miniature inhibitory postsynaptic currents / MGI
skeletal muscle hypoplasia / MGI
postnatal lethality, incomplete penetrance / MGI
decreased pons size / MGI

Literature references

entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.;Brill Julia, Klocke Rainer, Paul Dieter, Boison Detlev, Gouder Nicolette, Klugbauer Norbert, Hofmann Franz, Becker Cord-Michael, Becker Kristina, ;2004;The Journal of biological chemistry;279;7322-30; 14660671

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.

B6.D2(Cg)-Cacna2d2ent/Ieg