MGI phenotypes (allele matching)
B6.129S2-Cd207tm2Mal/Orl
| Status | Available to order |
| EMMA ID | EM:01819 |
| Citation information | RRID:IMSR_EM:01819 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Cd207tm2Mal/Orl |
| Alternative name | Langerin-EGFP |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Cd207tm2Mal |
| Gene/Transgene symbol | Cd207 |
Information from provider
| Provider | Adrien Kissenpfennig |
| Provider affiliation | Centre D |
| Genetic information | An IRES-EGFP cassette was targeted into the 3' UTR of the mouse langerin (Cd207) gene. |
| Phenotypic information | None. |
| Breeding history | The mutant mice were backcrossed for 10 generations to the C57BL/6 strain and are currently maintained as homozygotes. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal Peyer's patch morphology / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- increased susceptibility to viral infection / MGI
- abnormal type IV hypersensitivity reaction / MGI
- immune system phenotype / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal Langerhans cell morphology / MGI
- absent Langerhans cell / MGI
- decreased Langerhans cell number / MGI
- decreased dendritic cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG3 level / MGI
Literature references
- Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.;Kissenpfennig Adrien, Henri Sandrine, Dubois Bertrand, Laplace-Builhé Corinne, Perrin Pierre, Romani Nikolaus, Tripp Christoph H, Douillard Patrice, Leserman Lee, Kaiserlian Dominique, Saeland Sem, Davoust Jean, Malissen Bernard, ;2005;Immunity;22;643-54; 15894281