C3.C-Fbxl3Afh/H

Status

Available to order

EMMA IDEM:01841
Citation informationRRID:IMSR_EM:01841 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3.C-Fbxl3Afh/H
Alternative namePLAY68
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolFbxl3Afh
Gene/Transgene symbolFbxl3

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationWhen maintained in cages equipped with wheels under constant darkness, heterozygotes have a longer circadian period (24.12-24.23 hours) than wild-type.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating chloride level / IMPC
  • abnormal spleen morphology / IMPC
  • decreased spleen weight / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal skin morphology / IMPC
  • abnormal retina morphology / IMPC
  • abnormal brain morphology / IMPC
  • abnormal duodenum morphology / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased circulating total protein level / IMPC
  • increased lean body mass / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • enlarged heart / IMPC
  • abnormal heart morphology / IMPC
  • abnormal skeletal muscle morphology / IMPC
  • enlarged testis / IMPC
  • abnormal testis morphology / IMPC
  • decreased lean body mass / IMPC
  • hydrocephaly / IMPC
  • decreased liver weight / IMPC
MGI phenotypes (allele matching)
  • abnormal hypothalamus physiology / MGI
  • prolonged circadian behavior period / MGI
MGI phenotypes (gene matching)
  • abnormal hypothalamus physiology / MGI
  • abnormal circadian behavior / MGI
  • prolonged circadian behavior period / MGI
  • delayed circadian behavior phase / MGI
  • abnormal circardian behavior entrainment / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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