B6.129P2-Tln1tm1Crit/CritH

Status

Available to order

EMMA IDEM:00185
Citation informationRRID:IMSR_EM:00185 

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International strain nameB6.129P2-Tln1tm1Crit/CritH
Alternative nameTln1((hyg/+)/C57)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTln1tm1Crit
Gene/Transgene symbolTln1

Information from provider

ProviderMartin FRAY
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThe endogenous locus was disrupted by insertion of a hygromycin selection cassette. Codons 37 through 66 were deleted by the insertion.
Phenotypic informationTalin binds directly to selected integrin beta-subunit cytodomains and to F-actin. This interaction is disrupted in mice homozygous for this knock-out allele.
Breeding historyThe original founder stock has been repeatedly (more than 8 generations) backcrossed to C57BL/6J.
References
  • Disruption of the talin gene arrests mouse development at the gastrulation stage.;Monkley S J, Zhou X H, Kinston S J, Giblett S M, Hemmings L, Priddle H, Brown J E, Pritchard C A, Critchley D R, Fässler R, ;2000;Developmental dynamics : an official publication of the American Association of Anatomists;219;560-74; 11084655

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • abnormal mesoderm development / MGI
  • decreased embryo size / MGI
  • embryonic growth arrest / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal gastrulation movements / MGI
  • disorganized extraembryonic tissue / MGI
  • abnormal trophoblast layer morphology / MGI
  • abnormal extraembryonic mesoderm development / MGI
  • embryonic lethality, complete penetrance / MGI
  • abnormal amniotic cavity morphology / MGI
  • absent ectoplacental cavity / MGI
  • small proamniotic cavity / MGI
  • absent extraembryonic coelom / MGI
  • small amniotic cavity / MGI
  • embryonic-extraembryonic boundary constriction / MGI
MGI phenotypes (gene matching)
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • abnormal mesoderm development / MGI
  • decreased embryo size / MGI
  • embryonic growth arrest / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal gastrulation movements / MGI
  • disorganized extraembryonic tissue / MGI
  • abnormal trophoblast layer morphology / MGI
  • abnormal extraembryonic mesoderm development / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal proamniotic cavity morphology / MGI
  • abnormal amniotic cavity morphology / MGI
  • absent ectoplacental cavity / MGI
  • small proamniotic cavity / MGI
  • absent extraembryonic coelom / MGI
  • small amniotic cavity / MGI
  • embryonic-extraembryonic boundary constriction / MGI

Literature references

  • Disruption of the talin gene arrests mouse development at the gastrulation stage.;Monkley S J, Zhou X H, Kinston S J, Giblett S M, Hemmings L, Priddle H, Brown J E, Pritchard C A, Critchley D R, Fässler R, ;2000;Developmental dynamics : an official publication of the American Association of Anatomists;219;560-74; 11084655

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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