IMPC phenotypes (gene matching)
- decreased prepulse inhibition / IMPC
STOCK Aventm1.1Zrng/Ieg
| Status | Available to order |
| EMMA ID | EM:01886 |
| Citation information | RRID:IMSR_EM:01886 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Aventm1.1Zrng/Ieg |
| Alternative name | Aven knockout |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Aventm1.1Zrng |
| Gene/Transgene symbol | Aven |
Information from provider
| Provider | Martin Zoernig |
| Provider affiliation | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt |
| Genetic information | The wildtype Aven allele is targeted in a way that the first 200 amino acids within the first exon are replaced with a GFP cDNA including an ATG codon, with the endogenous Aven promoter driving GFP expression. GFP activity is observed and endogenous Aven protein expression has disappeared in the homozygous mice. The targeting construct contained a tk-neo fusion cassette flanked by loxP sites for positive selection. This cassette has been removed after breeding with CMV-cre recombinase deleter mice. |
| Phenotypic information | The homozygous mice appear normal, however cell death is increased in knock-out cells in vitro, after applying different apoptotic stimuli. The analysis is ongoing. |
| Breeding history | Backcrossed into C57BL/6 for 4 generations. |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |