B6;CBA-Tg(ACTB-gag/THRA1)AVen/VenKieg

Status	Available to order
EMMA ID	EM:00189
Citation information	RRID:IMSR_EM:00189 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;CBA-Tg(ACTB-gag/THRA1)AVen/VenKieg
Alternative name	v-erbA
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(ACTB-gag/THRA1)AVen
Gene/Transgene symbol	Tg(ACTB-gag/THRA1)AVen

Information from provider

Provider	Björn Vennström
Provider affiliation	Department of Cell and Molecular Biology, Karolinska Institutet, CMB
Genetic information	The v-erbA oncogene consists of an avian retroviral gag gene fused to a mutated thyroid hormone receptor. To better define its role as an oncogene in mammals and its ability to function as a dominant negative transcription factor, transgenic mice expressing v-erbA ubiquitously were generated.
Phenotypic information	The effects of v-erbA are pleiotropic, tissue-specific and dose dependent. Mice have breeding disorders, abnormal behavior, reduced adipose tissue, hypothyroidism with inappropriate thyroid stimulating hormone response, and enlarged seminal vesicles. This provides an animal model consistent with the proposal that v-erbA functions as a dominant negative receptor by transcriptional interference or squelching of normal receptors or associated proteins. Male animals develop hepatocellular carcinoma, demonstrating that v-erbA can promote neoplasia in mammals.
References	Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.;Barlow C, Meister B, Lardelli M, Lendahl U, Vennström B, ;1994;The EMBO journal;13;4241-50; 7925269 Altered expression after expansion of a v-erbA transgene in transgenic mice.;Barlow C, Meister B, Lendahl U, Vennström B, ;1995;Transgenic research;4;378-87; 7581518

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden
Stage of embryos	4/8-cell

Literature references

Thyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.;Barlow C, Meister B, Lardelli M, Lendahl U, Vennström B, ;1994;The EMBO journal;13;4241-50; 7925269
Altered expression after expansion of a v-erbA transgene in transgenic mice.;Barlow C, Meister B, Lendahl U, Vennström B, ;1995;Transgenic research;4;378-87; 7581518

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.