IMPC phenotypes (gene matching)
B6;129P2-Zfp423Gt(pT1Betageo)1Ruiz/WrstKieg
| Status | Available to order |
| EMMA ID | EM:00190 |
| Citation information | RRID:IMSR_EM:00190 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Zfp423Gt(pT1Betageo)1Ruiz/WrstKieg |
| Alternative name | W008G09 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Zfp423Gt(pT1Betageo)1Ruiz |
| Gene/Transgene symbol | Zfp423 |
Information from provider
| Provider | Thomas Floss |
| Provider affiliation | Institute of Developmental Genetics, Helmholtz Zentrum Muenchen |
| Phenotypic information | No defects detected. |
| Breeding history | Backcrossed to C57BL/6J for 4-6 generations. |
| References |
|
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI phenotypes (gene matching)
- tremors / MGI
- decreased brain size / MGI
- abnormal corpus callosum morphology / MGI
- abnormal forebrain morphology / MGI
- abnormal telencephalon morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal olfactory bulb morphology / MGI
- abnormal choroid plexus morphology / MGI
- dilated lateral ventricles / MGI
- dilated fourth ventricle / MGI
- abnormal medulla oblongata morphology / MGI
- abnormal cerebellum morphology / MGI
- absent cerebellum / MGI
- cerebellum hypoplasia / MGI
- small cerebellum / MGI
- abnormal cerebellum development / MGI
- abnormal cerebellar plate morphology / MGI
- abnormal cerebellum vermis morphology / MGI
- absent cerebellum vermis / MGI
- cerebellum vermis hypoplasia / MGI
- decreased Purkinje cell number / MGI
- ectopic Purkinje cell / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ataxia / MGI
- abnormal gait / MGI
- dehydration / MGI
- abnormal motor coordination/balance / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- absent corpus callosum / MGI
- abnormal nasal cavity morphology / MGI
- small olfactory bulb / MGI
- abnormal cerebellar cortex morphology / MGI
- abnormal olfactory nerve morphology / MGI
- behavior/neurological phenotype / MGI
- abnormal food intake / MGI
- abnormal hippocampal commissure morphology / MGI
- enlarged fourth ventricle / MGI
- enlarged lateral ventricles / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- abnormal olfactory epithelium morphology / MGI
- reduced cerebellar foliation / MGI
- abnormal interventricular foramen morphology / MGI
- abnormal cerebellum lateral hemisphere morphology / MGI
- abnormal cerebellar granule cell precursor proliferation / MGI
- lethality at weaning, complete penetrance / MGI
- lethality at weaning, incomplete penetrance / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- decreased hindbrain size / MGI
- small thalamus / MGI
Literature references
- OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.;Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J, ;2000;Cell;100;229-40; 10660046
- A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.;Hansen Jens, Floss Thomas, Van Sloun Petra, Füchtbauer Ernst-Martin, Vauti Franz, Arnold Hans-Hennig, Schnütgen Frank, Wurst Wolfgang, von Melchner Harald, Ruiz Patricia, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;9918-22; 12904583