MGI phenotypes (allele matching)
- loose skin / MGI
C3;CAnNCrl-Sagg/H
| Status | Available to order |
| EMMA ID | EM:01903 |
| Citation information | RRID:IMSR_EM:01903 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3;CAnNCrl-Sagg/H |
| Alternative name | GENA78 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Sagg |
| Gene/Transgene symbol | Sagg |
Information from provider
| Provider | Dr Patrick Nolan |
| Provider affiliation | MRC Harwell, Didcot, Oxon |
| Genetic information | Sagg maps to chromosome 1, lying between D1Mit232 and D1Mit234. Original mutant was offspring of a BALB/c male that received 160 mg/kg ENU mated to a C3H/HeH female. |
| Phenotypic information | Heterozygotes have loose skin that can be identified by weaning age. Their dermal phenotype is similar to some of the subtypes of Ehlers Danlos syndrome (EDS) and cutis laxa. Breeding data indicate that Sagg/+ has reduced penetrance and/or reduced viability - circa 75 percent. Litters from intercrosses failed to produce any pups with a more severe phenotype than that seen with heterozygotes, and litter size was markedly smaller than expected. Taken together this suggests that homozygotes are lost prenatally, but this has not formally been shown. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- loose skin / MGI
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191