STOCK Tg(Lck-AVEN)1Zrng/Ieg

Status	Available to order
EMMA ID	EM:01916
Citation information	RRID:IMSR_EM:01916 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Tg(Lck-AVEN)1Zrng/Ieg
Alternative name	lck Aven
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Lck-AVEN)1Zrng
Gene/Transgene symbol	Tg(Lck-AVEN)1Zrng

Information from provider

Provider	Martin Zoernig
Provider affiliation	Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, University of Frankfurt
Genetic information	Human AVEN cDNA was cloned and placed under control of the Lck promoter into the p1017 vector to achieve T cell-specific expression of the transgene.
Phenotypic information	The mice appear normal.
Breeding history	The transgenic mice were backcrossed for 4 generations to the C57BL/6 background.
References	Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.;Chau B N, Cheng E H, Kerr D A, Hardwick J M, ;2000;Molecular cell;6;31-40; 10949025 Involvement of p21ras distinguishes positive and negative selection in thymocytes.;Swan K A, Alberola-Ila J, Gross J A, Appleby M W, Forbush K A, Thomas J F, Perlmutter R M, ;1995;The EMBO journal;14;276-85; 7835338

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Literature references

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.;Chau B N, Cheng E H, Kerr D A, Hardwick J M, ;2000;Molecular cell;6;31-40; 10949025
Involvement of p21ras distinguishes positive and negative selection in thymocytes.;Swan K A, Alberola-Ila J, Gross J A, Appleby M W, Forbush K A, Thomas J F, Perlmutter R M, ;1995;The EMBO journal;14;276-85; 7835338

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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