B6.Cg-Tg(CMV-CAST)PM194Lbau/Orl
| Status | Available to order |
| EMMA ID | EM:01922 |
| Citation information | RRID:IMSR_EM:01922 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(CMV-CAST)PM194Lbau/Orl |
| Alternative name | Rabbit Calpastatin Tg Mice |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CMV-CAST)PM194Lbau |
| Gene/Transgene symbol | Tg(CMV-CAST)PM194Lbau |
Information from provider
| Provider | Agnes Bellocq |
| Provider affiliation | INSERM U702 |
| Genetic information | Insertion of the rabbit calpastatin (CAST) gene under the control of the CMV promoter. |
| Phenotypic information | Inhibition of the calpain-induced activity, unless phenotype affecting morphology, viability and fertility. |
| Breeding history | Backcrossed on C57BL/6J, N=9. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- Calpain activation and secretion promote glomerular injury in experimental glomerulonephritis: evidence from calpastatin-transgenic mice.;Peltier Julie, Bellocq Agnès, Perez Joëlle, Doublier Sophie, Dubois Yi-Chun Xu, Haymann Jean-Philippe, Camussi Giovanni, Baud Laurent, ;2006;Journal of the American Society of Nephrology : JASN;17;3415-23; 17082241
- A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.;Scalia Rosario, Gong Yulan, Berzins Brett, Freund Brin, Feather Danielle, Landesberg Gavin, Mishra Gourav, ;2011;Circulation research;108;1102-11; 21415394
- Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes.;Chen Bainian, Zhao Qing, Ni Rui, Tang Futian, Shan Limei, Cepinskas Inga, Cepinskas Gediminas, Wang Wang, Schiller Peter W, Peng Tianqing, ;2014;Cardiovascular diabetology;13;88; 24886224
- Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.;Zheng Dong, Wang Grace, Li Shuai, Fan Guo-Chang, Peng Tianqing, ;2015;Biochimica et biophysica acta;1852;882-92; 25660447
- Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.;Ni Rui, Zheng Dong, Wang Qiang, Yu Yong, Chen Ruizhen, Sun Tao, Wang Wang, Fan Guo-Chang, Greer Peter A, Gardiner Richard B, Peng Tianqing, ;2015;Circulation. Heart failure;8;988-96; 26246018
- Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.;Ni Rui, Zheng Dong, Xiong Sidong, Hill David J, Sun Tao, Gardiner Richard B, Fan Guo-Chang, Lu Yanrong, Abel E Dale, Greer Peter A, Peng Tianqing, ;2016;Diabetes;65;255-68; 26470784
- Over-expression of calpastatin attenuates myocardial injury following myocardial infarction by inhibiting endoplasmic reticulum stress.;Li Shuai, Ma Jian, Li Jing-Bo, Lacefield James C, Jones Douglas L, Peng Tian-Qing, Wei Meng, ;2018;Journal of thoracic disease;10;5283-5297; 30416776