STOCK Mut1397/H

Status	Available to order
EMMA ID	EM:01976
Citation information	RRID:IMSR_EM:01976 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Mut1397/H
Alternative name	MUT/1397
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Mut1397
Gene/Transgene symbol	Mut1397

Information from provider

Provider	Bruce Cattanach
Provider affiliation	MRC Harwell, Didcot, Oxon, OX11 0RD
Genetic information	Original mutant was offspring of (C3H/HeH x 101/H)F1 male that received ethyl-nitrosourea (ENU) + triethylenemelamine (TEM), mated to tester stock (PT) female.
Phenotypic information	Heterozygotes: shortened tail with mild to severe kinking and blunt tail tip. Homozygous lethal. Heterozygotes: viability good, but reduced penetrance of phenotype on crossing to 3H1 (circa 70%), much more reduced on crossing to Mus castaneus. Opening and breeding data indicate that homozygotes are lost pre- and early post-implantation. Allelism test with t^h2 (MGI:1856184) showed Mut1397 not to be an allele of T (MGI:1856184).
Breeding history	Original background: (C3H/HeH x 101/H) x PT. Maintained background: C3H/HeH x 101/H. Breeding History: Backcrossed to C3H/HeH x 101/H.
References	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)

embryonic lethality / MGI
kinked tail / MGI
short tail / MGI
abnormal tail morphology / MGI

MGI phenotypes (gene matching)

kinked tail / MGI
short tail / MGI
abnormal tail morphology / MGI
embryonic lethality / MGI

Literature references

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

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