C57BL/6-Tg(Fabp1-NTN1)6Mhln/Orl
| Status | Available to order |
| EMMA ID | EM:01980 |
| Citation information | RRID:IMSR_EM:01980 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Fabp1-NTN1)6Mhln/Orl |
| Alternative name | Tg6-netrin-1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Fabp1-NTN1)6Mhln |
| Gene/Transgene symbol | Tg(Fabp1-NTN1)6Mhln |
Information from provider
| Provider | Patrick Mehlen |
| Provider affiliation | CNRS FRE2870 |
| Genetic information | The transgene contains chick netrin 1 cDNA under the gut-specific Fabpl (Fabp1) promoter. |
| Phenotypic information | Decrease of apoptotic cells in the intestinal epithelia. Spontaneous formation of hyperplastic and neoplastic lesions in gastrointestinal tract. Occasional polycystic kidney. |
| Breeding history | Animals are currently being maintained as hemizygotes by matings with C57BL/6. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.;Mazelin Laetitia, Bernet Agnès, Bonod-Bidaud Christelle, Pays Laurent, Arnaud Ségolène, Gespach Christian, Bredesen Dale E, Scoazec Jean-Yves, Mehlen Patrick, ;2004;Nature;431;80-4; 15343335
- Netrin-1 Overexpression Induces Polycystic Kidney Disease: A Novel Mechanism Contributing to Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.;Mohamed Riyaz, Liu Yang, Kistler Andreas D, Harris Peter C, Thangaraju Muthusamy, ;2022;The American journal of pathology;192;862-875; 35358475