IMPC phenotypes (gene matching)
C3.Cg-Gapdhm3Neu/Ieg
| Status | Available to order |
| EMMA ID | EM:02014 |
| Citation information | RRID:IMSR_EM:02014 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3.Cg-Gapdhm3Neu/Ieg |
| Alternative name | GAPDH3284 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Gapdhm3Neu |
| Gene/Transgene symbol | Gapdh |
Information from provider
| Provider | Walter Pretsch |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | The mutation is a T-to-A transversion at codon 328 in exon 6. This is predicted to alter a tyrosine (TAC) in an asparagine (AAC). |
| Phenotypic information | Glyceraldehyde-3-phosphate dehydrogenase deficiency (approximately 50% residual activity in heterozygous mutants) in blood. |
| Breeding history | Always backcrossing of heterozygous mutant animals with C3H animals. |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal hematocrit / MGI
- decreased hemoglobin content / MGI
- renal/urinary system phenotype / MGI
- liver/biliary system phenotype / MGI
- growth/size/body region phenotype / MGI
- cardiovascular system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal enzyme/coenzyme activity / MGI
- decreased survivor rate / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity / MGI
Literature references
- Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice.;Charles D J, Pretsch W, ;1987;Mutation research;176;81-91; 3796661
- Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations.;Pretsch W, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;537-42; 10886019
- Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus.;Pretsch Walter, Favor Jack, ;2007;Mammalian genome : official journal of the International Mammalian Genome Society;18;686-92; 17874335