B6.129-Hoxb4tm1Karl/Kctt

Status

Available to order

EMMA IDEM:02068
Citation informationRRID:IMSR_EM:02068 

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International strain nameB6.129-Hoxb4tm1Karl/Kctt
Alternative nameHoxb4Flox
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolHoxb4tm1Karl
Gene/Transgene symbolHoxb4

Information from provider

ProviderStefan Karlsson
Provider affiliationInstitute of Laboratory Medicine, The Lund Strategic Center for Stem Cell Biology and Cell Therapy
Genetic informationThe whole Hoxb4 sequence was flanked by loxP sites.
Phenotypic informationNot characterized.
References
  • Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.;Björnsson Jon Mar, Larsson Nina, Brun Ann C M, Magnusson Mattias, Andersson Elisabet, Lundström Patrik, Larsson Jonas, Repetowska Ewa, Ehinger Mats, Humphries R Keith, Karlsson Stefan, ;2003;Molecular and cellular biology;23;3872-83; 12748289
  • Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.;Brun Ann C M, Björnsson Jon Mar, Magnusson Mattias, Larsson Nina, Leveén Per, Ehinger Mats, Nilsson Eva, Karlsson Stefan, ;2004;Blood;103;4126-33; 14962901

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal sternum morphology / MGI
  • abnormal heart morphology / MGI
  • thin ventricular wall / MGI
  • decreased bone marrow cell number / MGI
  • spleen hypoplasia / MGI
  • decreased body size / MGI
  • edema / MGI
  • respiratory distress / MGI
  • abnormal definitive hematopoiesis / MGI
  • no abnormal phenotype detected / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • abnormal cervical vertebrae morphology / MGI
  • abnormal abdominal wall morphology / MGI
  • abnormal ventral body wall morphology / MGI
  • abnormal body wall morphology / MGI
  • absent pericardium / MGI
  • pallor / MGI
  • diaphragmatic hernia / MGI
  • abnormal chest morphology / MGI
  • split sternum / MGI
  • abnormal sternebra morphology / MGI
  • abnormal cervical axis morphology / MGI
  • cervical vertebral transformation / MGI
  • muscle phenotype / MGI
  • growth/size/body region phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal heart position or orientation / MGI
  • dilated heart ventricle / MGI
  • decreased survivor rate / MGI
  • thin interventricular septum / MGI
  • mortality/aging / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI

Literature references

  • Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.;Björnsson Jon Mar, Larsson Nina, Brun Ann C M, Magnusson Mattias, Andersson Elisabet, Lundström Patrik, Larsson Jonas, Repetowska Ewa, Ehinger Mats, Humphries R Keith, Karlsson Stefan, ;2003;Molecular and cellular biology;23;3872-83; 12748289
  • Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.;Brun Ann C M, Björnsson Jon Mar, Magnusson Mattias, Larsson Nina, Leveén Per, Ehinger Mats, Nilsson Eva, Karlsson Stefan, ;2004;Blood;103;4126-33; 14962901

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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