MGI phenotypes (allele matching)
B6.129-Hoxb4tm1.1Karl/Kctt
| Status | Available to order |
| EMMA ID | EM:02069 |
| Citation information | RRID:IMSR_EM:02069 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Hoxb4tm1.1Karl/Kctt |
| Alternative name | Hoxb4 knockout |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hoxb4tm1.1Karl |
| Gene/Transgene symbol | Hoxb4 |
Information from provider
| Provider | Stefan Karlsson |
| Provider affiliation | Institute of Laboratory Medicine, The Lund Strategic Center for Stem Cell Biology and Cell Therapy |
| Genetic information | The whole Hoxb4 coding sequence has been deleted. |
| Phenotypic information | See: Brun AC, Bjornsson JM, Magnusson M, Larsson N, Leveen P, Ehinger M, Nilsson E, Karlsson S. Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood. 2004 Jun 1;103(11):4126-33. Epub 2004 Feb 12. Bjornsson JM, Larsson N, Brun AC, Magnusson M, Andersson E, Lundstrom P, Larsson J, Repetowska E, Ehinger M, Humphries RK, Karlsson S. Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Mol Cell Biol. 2003 Jun;23(11):3872-83. |
| References |
|
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal sternum morphology / MGI
- abnormal heart morphology / MGI
- thin ventricular wall / MGI
- decreased bone marrow cell number / MGI
- spleen hypoplasia / MGI
- decreased body size / MGI
- edema / MGI
- respiratory distress / MGI
- abnormal definitive hematopoiesis / MGI
- no abnormal phenotype detected / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- abnormal cervical vertebrae morphology / MGI
- abnormal abdominal wall morphology / MGI
- abnormal ventral body wall morphology / MGI
- abnormal body wall morphology / MGI
- absent pericardium / MGI
- pallor / MGI
- diaphragmatic hernia / MGI
- abnormal chest morphology / MGI
- split sternum / MGI
- abnormal sternebra morphology / MGI
- abnormal cervical axis morphology / MGI
- cervical vertebral transformation / MGI
- muscle phenotype / MGI
- growth/size/body region phenotype / MGI
- skeleton phenotype / MGI
- abnormal heart position or orientation / MGI
- dilated heart ventricle / MGI
- decreased survivor rate / MGI
- thin interventricular septum / MGI
- mortality/aging / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
Literature references
- Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.;Björnsson Jon Mar, Larsson Nina, Brun Ann C M, Magnusson Mattias, Andersson Elisabet, Lundström Patrik, Larsson Jonas, Repetowska Ewa, Ehinger Mats, Humphries R Keith, Karlsson Stefan, ;2003;Molecular and cellular biology;23;3872-83; 12748289
- Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.;Brun Ann C M, Björnsson Jon Mar, Magnusson Mattias, Larsson Nina, Leveén Per, Ehinger Mats, Nilsson Eva, Karlsson Stefan, ;2004;Blood;103;4126-33; 14962901