B6.129-Del(11Hoxb3-Hoxb4)1Karl/Kctt

Status	Available to order
EMMA ID	EM:02071
Citation information	RRID:IMSR_EM:02071 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129-Del(11Hoxb3-Hoxb4)1Karl/Kctt
Alternative name	Hoxb3/Hoxb4 knockout
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Del(11Hoxb3-Hoxb4)1Karl
Gene/Transgene symbol	Del(11Hoxb3-Hoxb4)1Karl

Information from provider

Provider	Stefan Karlsson
Provider affiliation	Institute of Laboratory Medicine, The Lund Strategic Center for Stem Cell Biology and Cell Therapy
Genetic information	The whole Hoxb3 and Hoxb4 has been deleted.
Phenotypic information	See: Brun AC, Bjornsson JM, Magnusson M, Larsson N, Leveen P, Ehinger M, Nilsson E, Karlsson S. Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood. 2004 Jun 1;103(11):4126-33. Epub 2004 Feb 12. Bjornsson JM, Larsson N, Brun AC, Magnusson M, Andersson E, Lundstrom P, Larsson J, Repetowska E, Ehinger M, Humphries RK, Karlsson S. Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Mol Cell Biol. 2003 Jun;23(11):3872-83.
Breeding history	Backcrossed 8 times into C57BL/6.
References	Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.;Björnsson Jon Mar, Larsson Nina, Brun Ann C M, Magnusson Mattias, Andersson Elisabet, Lundström Patrik, Larsson Jonas, Repetowska Ewa, Ehinger Mats, Humphries R Keith, Karlsson Stefan, ;2003;Molecular and cellular biology;23;3872-83; 12748289 Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.;Brun Ann C M, Björnsson Jon Mar, Magnusson Mattias, Larsson Nina, Leveén Per, Ehinger Mats, Nilsson Eva, Karlsson Stefan, ;2004;Blood;103;4126-33; 14962901

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)

decreased bone marrow cell number / MGI
abnormal liver morphology / MGI
abnormal spleen morphology / MGI
spleen hypoplasia / MGI
decreased body weight / MGI
abnormal definitive hematopoiesis / MGI
decreased hemoglobin content / MGI
decreased erythrocyte cell number / MGI
abnormal hematopoietic stem cell morphology / MGI
decreased spleen weight / MGI
skeleton phenotype / MGI
abnormal common myeloid progenitor cell morphology / MGI

MGI phenotypes (gene matching)

decreased bone marrow cell number / MGI
abnormal liver morphology / MGI
abnormal spleen morphology / MGI
spleen hypoplasia / MGI
decreased body weight / MGI
abnormal definitive hematopoiesis / MGI
decreased hemoglobin content / MGI
decreased erythrocyte cell number / MGI
abnormal hematopoietic stem cell morphology / MGI
decreased spleen weight / MGI
skeleton phenotype / MGI
abnormal common myeloid progenitor cell morphology / MGI

Literature references

Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.;Björnsson Jon Mar, Larsson Nina, Brun Ann C M, Magnusson Mattias, Andersson Elisabet, Lundström Patrik, Larsson Jonas, Repetowska Ewa, Ehinger Mats, Humphries R Keith, Karlsson Stefan, ;2003;Molecular and cellular biology;23;3872-83; 12748289
Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.;Brun Ann C M, Björnsson Jon Mar, Magnusson Mattias, Larsson Nina, Leveén Per, Ehinger Mats, Nilsson Eva, Karlsson Stefan, ;2004;Blood;103;4126-33; 14962901

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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