MGI phenotypes (allele matching)
CD2-Hk2tm1Laak/Kctt
| Status | Available to order |
| EMMA ID | EM:02073 |
| Citation information | RRID:IMSR_EM:02073 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CD2-Hk2tm1Laak/Kctt |
| Alternative name | Ukko1; Hk2+/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hk2tm1Laak |
| Gene/Transgene symbol | Hk2 |
Information from provider
| Provider | Sami Heikkinen |
| Provider affiliation | IGBMC |
| Genetic information | A neomycin resistance cassette was inserted into exon 4 of mouse hexokinase 2 (Hk2) gene. |
| Phenotypic information | Homozygotes die approximately at embryonic day 7. Heterozygotes are viable but have about 50% reduction in Hk2 enzyme activity in heart, skeletal muscle and white adipose tissue. |
| References |
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Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial atrial fibrillation / Orphanet_334
Literature references
- Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.;Heikkinen S, Pietilä M, Halmekytö M, Suppola S, Pirinen E, Deeb S S, Jänne J, Laakso M, ;1999;The Journal of biological chemistry;274;22517-23; 10428828
- Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice.;Fueger Patrick T, Heikkinen Sami, Bracy Deanna P, Malabanan Carlo M, Pencek R Richard, Laakso Markku, Wasserman David H, ;2003;American journal of physiology. Endocrinology and metabolism;285;E958-63; 12865258
- Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse.;Fueger Patrick T, Shearer Jane, Krueger Tess M, Posey Kelly A, Bracy Deanna P, Heikkinen Sami, Laakso Markku, Rottman Jeffrey N, Wasserman David H, ;2005;The Journal of physiology;566;533-41; 15878951