B6;129P2-Del(16Hspa13-App)3Yah/Orl

Status	Available to order
EMMA ID	EM:02100
Citation information	RRID:IMSR_EM:02100 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129P2-Del(16Hspa13-App)3Yah/Orl
Alternative name	Del (Stch-App)Ms3Yah
Strain type	Targeted Mutant Strains : Other targeted
Allele/Transgene symbol	Del(16Hspa13-App)3Yah
Gene/Transgene symbol	Del(16Hspa13-App)3Yah

Information from provider

Provider	Yann HERAULT
Provider affiliation	TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models
Genetic information	Deletion of the region between the Hspa13 (Stch) and App genes engineered using MICER in ES (HM-1) cells.
Phenotypic information	Heterozygotes: No major defects.
Breeding history	Deletion generated in 129P2 HM-1 ES cells. Cells injected in C57BL/6 blastocysts. Backcross on C57BL/6.
References	Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.;Brault Véronique, Duchon Arnaud, Romestaing Caroline, Sahun Ignasi, Pothion Stéphanie, Karout Mona, Borel Christelle, Dembele Doulaye, Bizot Jean-Charles, Messaddeq Nadia, Sharp Andrew J, Roussel Damien, Antonarakis Stylianos E, Dierssen Mara, Hérault Yann, ;2015;PLoS genetics;11;e1005062; 25803843 Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.;Duchon Arnaud, Del Mar Muniz Moreno Maria, Martin Lorenzo Sandra, Silva de Souza Marcia Priscilla, Chevalier Claire, Nalesso Valérie, Meziane Hamid, Loureiro de Sousa Paulo, Noblet Vincent, Armspach Jean-Paul, Brault Veronique, Herault Yann, ;2021;Human molecular genetics;30;771-788; 33693642 Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)

abnormal skeletal muscle morphology / MGI
decreased body weight / MGI
hyperactivity / MGI
abnormal muscle physiology / MGI
enhanced coordination / MGI
decreased skeletal muscle mass / MGI
abnormal mitochondrial physiology / MGI
abnormal skeletal muscle fiber type ratio / MGI
decreased grip strength / MGI
abnormal cellular respiration / MGI
abnormal mitochondrial chromosome morphology / MGI

MGI phenotypes (gene matching)

abnormal skeletal muscle morphology / MGI
decreased body weight / MGI
hyperactivity / MGI
abnormal muscle physiology / MGI
enhanced coordination / MGI
decreased skeletal muscle mass / MGI
abnormal mitochondrial physiology / MGI
abnormal skeletal muscle fiber type ratio / MGI
decreased grip strength / MGI
abnormal cellular respiration / MGI
abnormal mitochondrial chromosome morphology / MGI

Literature references

Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.;Brault Véronique, Duchon Arnaud, Romestaing Caroline, Sahun Ignasi, Pothion Stéphanie, Karout Mona, Borel Christelle, Dembele Doulaye, Bizot Jean-Charles, Messaddeq Nadia, Sharp Andrew J, Roussel Damien, Antonarakis Stylianos E, Dierssen Mara, Hérault Yann, ;2015;PLoS genetics;11;e1005062; 25803843
Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.;Duchon Arnaud, Del Mar Muniz Moreno Maria, Martin Lorenzo Sandra, Silva de Souza Marcia Priscilla, Chevalier Claire, Nalesso Valérie, Meziane Hamid, Loureiro de Sousa Paulo, Noblet Vincent, Armspach Jean-Paul, Brault Veronique, Herault Yann, ;2021;Human molecular genetics;30;771-788; 33693642
Rodent models in Down syndrome research: impact and future opportunities.;Herault Yann, Delabar Jean M, Fisher Elizabeth M C, Tybulewicz Victor L J, Yu Eugene, Brault Veronique, ;2017;Disease models & mechanisms;10;1165-1186; 28993310

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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