MGI phenotypes (allele matching)
STOCK Igh-8tm2(Ighg1)Aak/Orl
| Status | Available to order |
| EMMA ID | EM:02110 |
| Citation information | RRID:IMSR_EM:02110 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Igh-8tm2(Ighg1)Aak/Orl |
| Alternative name | Ig1/Ig3 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Igh-8tm2(Ighg1)Aak |
| Gene/Transgene symbol | Igh-8 |
Information from provider
| Provider | Ahmed Amine Khamlichi |
| Provider affiliation | CNRS UMR 6101 |
| Genetic information | The targeting construct is from 129 DNA. The Ig3 germline promoter was replaced by Ig1 germline promoter leading to a duplication of Ig1 promoter within the IgH locus. |
| Phenotypic information | Inhibition of class switching to IgG3 despite abundant germline transcription. |
| Breeding history | Bred with C57BL/6 for several generations. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Literature references
- Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.;Oruc Zeliha, Boumédiène Ahmed, Le Bert Marc, Khamlichi Ahmed Amine, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;20484-9; 18077389