B6.129-Tnfrsf10btm1Frl/Orl

Status

Available to order

EMMA IDEM:02220
Citation informationRRID:IMSR_EM:02220 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Tnfrsf10btm1Frl/Orl
Alternative nameTNFRSF10-/- or Trail-R KI
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolTnfrsf10btm1Frl
Gene/Transgene symbolTnfrsf10b

Information from provider

ProviderFrédéric Rieux-laucat
Provider affiliationINSERM U 768
Genetic informationPoint mutation which introduces a STOP codon at the beginning of death domain.
Phenotypic informationNo phenotypic defect.
Breeding historyMore than 10 backcrosses to C57BL/6.
ReferencesNone available

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

MGI phenotypes (gene matching)
  • enlarged thymus / MGI
  • increased metastatic potential / MGI
  • decreased susceptibility to viral infection / MGI
  • abnormal innate immunity / MGI
  • no phenotypic analysis / MGI
  • decreased cellular sensitivity to gamma-irradiation / MGI
  • increased NK cell number / MGI
  • increased tumor necrosis factor secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • increased circulating interleukin-12b level / MGI
  • increased interleukin-12 secretion / MGI
  • abnormal interferon level / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased susceptibility to viral infection induced morbidity/mortality / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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