B6.129X1-Gdf1tm1Dmus/Kctt

Status

Available to order

EMMA IDEM:02230
Citation informationRRID:IMSR_EM:02230 

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International strain nameB6.129X1-Gdf1tm1Dmus/Kctt
Alternative nameGdf1-flox
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolGdf1tm1Dmus
Gene/Transgene symbolGdf1

Information from provider

ProviderTed Ebendal
Provider affiliationDepartment of Neuroscience, Uppsala University
Genetic informationLoxP sites were introduced in introns flanking exon 2. The Neo cassette (flanked by frt sites) was eliminated in vivo by crossing with FLP deleters.
Phenotypic informationMice carrying the Gdf1 floxed allele appear normal (also homozygotes). The floxed allele can be eliminated by crossing with a Cre deleter and result in many pups with situs inversus as described from the original Gdf1 knockout. We have eliminated Gdf1 in various nerve cells in the mouse (by cell specific Cre expression) and have seen only small effects.
References
  • Generation and characterization of a Gdf1 conditional null allele.;Bengtsson Henrik, Epifantseva Irina, Abrink Magnus, Kylberg Annika, Kullander Klas, Ebendal Ted, Usoskin Dmitry, ;2008;Genesis (New York, N.Y. : 2000);46;368-72; 18615710

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal digestive system morphology / MGI
  • right pulmonary isomerism / MGI
  • abnormal liver morphology / MGI
  • dextrocardia / MGI
  • abnormal spleen morphology / MGI
  • abnormal left-right axis patterning / MGI
  • abnormal kidney morphology / MGI
  • situs inversus / MGI
  • transposition of great arteries / MGI
  • heterotaxia / MGI
  • abnormal vena cava morphology / MGI
  • annular pancreas / MGI
  • ventricular septal defect / MGI
  • atrial septal defect / MGI
  • complete atrioventricular septal defect / MGI
  • neonatal lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI

Literature references

  • Generation and characterization of a Gdf1 conditional null allele.;Bengtsson Henrik, Epifantseva Irina, Abrink Magnus, Kylberg Annika, Kullander Klas, Ebendal Ted, Usoskin Dmitry, ;2008;Genesis (New York, N.Y. : 2000);46;368-72; 18615710
  • Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.;Zhang Yan, Zhang Xiao-Fei, Gao Lu, Liu Yu, Jiang Ding-Sheng, Chen Ke, Yang Qinglin, Fan Guo-Chang, Zhang Xiao-Dong, Huang Congxin, ;2014;Biochimica et biophysica acta;1842;232-44; 24275554

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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