C3El.Cg-Mdh1m8Neu/Ieg

Status

Available to order

EMMA IDEM:02262
Citation informationRRID:IMSR_EM:02262 

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International strain nameC3El.Cg-Mdh1m8Neu/Ieg
Alternative nameMDH7836
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolMdh1m8Neu
Gene/Transgene symbolMdh1

Information from provider

ProviderWalter Pretsch
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThe mutation causes a deletion of amino acids 264 to 293 (= Exon 8).
Phenotypic informationMalate dehydrogenase (EC 1.1.1.37) deficiency (approximately 55% residual activity in heterozygous mutants) in blood (and in other organs).
Breeding historyC3H/El (22nd generation).
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • thick ventricular wall / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal pharyngeal arch morphology / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • decreased exploration in new environment / IMPC
MGI phenotypes (allele matching)
  • no phenotypic analysis / MGI
MGI phenotypes (gene matching)
  • no phenotypic analysis / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • prenatal lethality, complete penetrance / MGI

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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