IMPC phenotypes (gene matching)
C3El.Cg-Mdh1m5Neu/Ieg
| Status | Available to order |
| EMMA ID | EM:02265 |
| Citation information | RRID:IMSR_EM:02265 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3El.Cg-Mdh1m5Neu/Ieg |
| Alternative name | MDH26405 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Mdh1m5Neu |
| Gene/Transgene symbol | Mdh1 |
Information from provider
| Provider | Walter Pretsch |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | The mutation is a T-to-A transversion at codon 292 in exon 8. This is predicted to alter an isoleucine (ATC) in an asparagine (AAC). |
| Phenotypic information | Malate dehydrogenase (EC 1.1.1.37) deficiency (approximately 55% residual activity in heterozygous and approximately 5% residual activity in homozygous mutants) in blood (and in other organs). |
| Breeding history | C3H/El (42nd generation). |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Literature references
- Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice.;Charles D J, Pretsch W, ;1987;Mutation research;176;81-91; 3796661
- Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations.;Pretsch W, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;537-42; 10886019