IMPC phenotypes (gene matching)
B6.129(Cg)-Asic3tm1Pig/Ieg
| Status | Available to order |
| EMMA ID | EM:02268 |
| Citation information | RRID:IMSR_EM:02268 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129(Cg)-Asic3tm1Pig/Ieg |
| Alternative name | ASIC tm1zim |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Asic3tm1Pig |
| Gene/Transgene symbol | Asic3 |
Information from provider
| Provider | Andreas Zimmer |
| Provider affiliation | Institute of Molecular Psychiatry |
| Genetic information | Exons 2-11 were replaced with a lacZ-neo cassette by homologous recombination in embryonic stem cells. This deletion removes the second transmembrane domain and most of the extracellular domain. PMID: 12060708. |
| Phenotypic information | Behavioral abnormalities, reduced THC dysphoria. |
| Breeding history | Backcrossed for at least 10 generations to C57BL/6J mice. |
| References |
|
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal sensory neuron morphology / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal mechanical nociception / MGI
- hyperresponsive to tactile stimuli / MGI
- nervous system phenotype / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal rod electrophysiology / MGI
- abnormal brainstem morphology / MGI
- behavior/neurological phenotype / MGI
- hyperalgesia / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal eye electrophysiology / MGI
- abnormal retinal apoptosis / MGI
- retinal ganglion cell degeneration / MGI
- amacrine cell degeneration / MGI
- disorganized retinal inner nuclear layer / MGI
- disorganized retinal outer nuclear layer / MGI
- retinal outer nuclear layer degeneration / MGI
- thin retinal outer plexiform layer / MGI
- decreased chemical nociceptive threshold / MGI
- photoreceptor inner segment degeneration / MGI
- photoreceptor outer segment degeneration / MGI
- abnormal physiological response to xenobiotic / MGI
- increased or absent threshold for auditory brainstem response / MGI
Literature references
- A role for ASIC3 in the modulation of high-intensity pain stimuli.;Chen Chih-Cheng, Zimmer Anne, Sun Wei-Hsin, Hall Jennifer, Brownstein Michael J, Zimmer Andreas, ;2002;Proceedings of the National Academy of Sciences of the United States of America;99;8992-7; 12060708