IMPC phenotypes (gene matching)
B6;129P2-Hspa13tm1Yah Apptm1Yah/++/Orl
| Status | Available to order |
| EMMA ID | EM:02387 |
| Citation information | RRID:IMSR_EM:02387 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Hspa13tm1Yah Apptm1Yah/++/Orl |
| Alternative name | SA218 cis(Stch-App) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Apptm1Yah, Hspa13tm1Yah |
| Gene/Transgene symbol | App, Hspa13 |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models |
| Genetic information | Insertion by homologous recombination in ES cells using two targeting vectors derived from the MICER resource, one containing a loxP site at the Stch (Hspa13) locus and a second vector containing a loxP site at the App locus, in a cis configuration. The mouse line was established from the SA218 ES cell clone. |
| Phenotypic information | No visible phenotype. |
| Breeding history | LoxP insertions at loci Stch (Hspa13) and App were generated in a cis configuration in 129P2 ES cells. Cells were injected in C57BL/6J blastocysts, backcrossed on C57BL/6J and then intercrossed. F2, N4, G6 at present. |
| References | None available |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- ABeta amyloidosis, Italian type / Orphanet_324713
- ABetaL34V amyloidosis / Orphanet_324703
- ABeta amyloidosis, Arctic type / Orphanet_324723
- ABetaA21G amyloidosis / Orphanet_324718
- ABeta amyloidosis, Dutch type / Orphanet_100006
- ABeta amyloidosis, Iowa type / Orphanet_324708
- Early-onset autosomal dominant Alzheimer disease / Orphanet_1020
MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
MGI phenotypes (gene matching)
- amyloidosis / MGI
- muscle degeneration / MGI
- decreased corpus callosum size / MGI
- abnormal telencephalon morphology / MGI
- decreased body weight / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- decreased exploration in new environment / MGI
- abnormal cued conditioning behavior / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- impaired swimming / MGI
- intracerebral hemorrhage / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal fear/anxiety-related behavior / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal brain morphology / MGI
- no abnormal phenotype detected / MGI
- decreased brain weight / MGI
- gliosis / MGI
- absent corpus callosum / MGI
- abnormal brain commissure morphology / MGI
- abnormal long term potentiation / MGI
- abnormal emotion/affect behavior / MGI
- increased thigmotaxis / MGI
- abnormal active avoidance behavior / MGI
- abnormal long term object recognition memory / MGI
- abnormal neuron morphology / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- amyloid beta deposits / MGI
- astrocytosis / MGI
- nervous system phenotype / MGI
- impaired passive avoidance behavior / MGI
- myositis / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal cell physiology / MGI
- decreased hippocampal commissure size / MGI
- decreased anterior commissure size / MGI
- abnormal spatial reference memory / MGI
- hematoma / MGI
- microgliosis / MGI
- increased variability of skeletal muscle fiber size / MGI
- centrally nucleated skeletal muscle fibers / MGI
- abnormal synapse morphology / MGI
- decreased grip strength / MGI
- altered susceptibility to induced thrombosis / MGI
- abnormal circadian behavior / MGI