B6129-Gnaqtm1Soff/Orl

Status

Available to order

EMMA IDEM:02422
Citation informationRRID:IMSR_EM:02422 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6129-Gnaqtm1Soff/Orl
Alternative nameGalpha q
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGnaqtm1Soff
Gene/Transgene symbolGnaq

Information from provider

ProviderStefan Offermanns
Provider affiliationUNIVERSITAT HEIDELBERG
Genetic informationA neomycin resistance cassette replaced 2.3 kb of sequence containing the exon encoding amino acids 246-297 of the protein. For details see: Offermanns S., PNAS 1997, Vol.94 14089-14094 PMID: 9391157.
Phenotypic informationImpaired motor coordination and platelet aggregation.
References
  • Defective platelet activation in G alpha(q)-deficient mice.;Offermanns S, Toombs C F, Hu Y H, Simon M I, ;1997;Nature;389;183-6; 9296496
  • Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq.;Offermanns S, Hashimoto K, Watanabe M, Sun W, Kurihara H, Thompson R F, Inoue Y, Kano M, Simon M I, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;14089-94; 9391157

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased platelet aggregation / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • absent long term depression / MGI
  • abnormal innervation / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal glutamate-mediated receptor currents / MGI
  • abnormal afterhyperpolarization / MGI
  • nervous system phenotype / MGI
  • abnormal platelet physiology / MGI
  • increased bleeding time / MGI
  • neonatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • increased foot pad pigmentation / MGI
  • hyperpigmentation / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • abnormal motor coordination/balance / MGI
  • absent long term depression / MGI
  • abnormal skin pigmentation / MGI
  • abnormal innervation / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal blood coagulation / MGI
  • abnormal glutamate-mediated receptor currents / MGI
  • abnormal afterhyperpolarization / MGI
  • nervous system phenotype / MGI
  • darkened coat color / MGI
  • abnormal platelet physiology / MGI
  • increased bleeding time / MGI
  • abnormal dermal pigmentation / MGI
  • abnormal epidermal pigmentation / MGI
  • decreased platelet aggregation / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • increased tail pigmentation / MGI
  • increased ear pigmentation / MGI

Literature references

  • Defective platelet activation in G alpha(q)-deficient mice.;Offermanns S, Toombs C F, Hu Y H, Simon M I, ;1997;Nature;389;183-6; 9296496
  • Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq.;Offermanns S, Hashimoto K, Watanabe M, Sun W, Kurihara H, Thompson R F, Inoue Y, Kano M, Simon M I, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;14089-94; 9391157

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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