STOCK Xpo4Gt(PT1-ATG)3EVal/H

Status

Available to order

EMMA IDEM:02468
Citation informationRRID:IMSR_EM:02468 

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International strain nameSTOCK Xpo4Gt(PT1-ATG)3EVal/H
Alternative name3E
Strain typeGene-trap
Allele/Transgene symbolXpo4Gt(PT1-ATG)3EVal
Gene/Transgene symbolXpo4

Information from provider

ProviderKatherine Vallis
Provider affiliationRadiation Oncology and Biology, University of Oxford
Genetic informationThe gene-trap vector PT1-ATG (also known as PT1) was used. It contains the En-2 splice acceptor site fused to the promoterless lacZ reporter gene with an ATG translational start site. PT1 also contains the bacterial neomycin-resistance gene, neo, driven by the PGK-1 promoter. In the case of 3E the integration site of the gene-trap vector is 34 bp upstream of the start site (ATG) of the exportin 4 gene.
Phenotypic informationPhenotypically normal
References
  • Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.;Lipowsky G, Bischoff F R, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Görlich D, ;2000;The EMBO journal;19;4362-71; 10944119

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Breeding at archiving centreMales were archived by sperm freezing on arrival. No breeding was performed at the archiving centre. Males may be either homozygous or heterozygous for the mutation. Carriers of the mutation are identified by the presence or absence of lacZ sequence on Southern blots.

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • edema / IMPC
  • microphthalmia / IMPC
  • abnormal retina morphology / IMPC
MGI phenotypes (gene matching)
  • no abnormal phenotype detected / MGI

Literature references

  • Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes.;Lipowsky G, Bischoff F R, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Görlich D, ;2000;The EMBO journal;19;4362-71; 10944119

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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