- persistence of hyaloid vascular system / IMPC
- irregularly shaped pupil / IMPC
- decreased circulating phosphate level / IMPC
- impaired pupillary reflex / IMPC
- abnormal placement of pupils / IMPC
- abnormal retina blood vessel morphology / IMPC
- abnormal retina morphology / IMPC
- abnormal locomotor behavior / IMPC
B6.129P2-Sema3eGt(RST629)Byg/Ieg
| Status | Available to order |
| EMMA ID | EM:02473 |
| Citation information | RRID:IMSR_EM:02473 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Sema3eGt(RST629)Byg/Ieg |
| Alternative name | RST629 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Sema3eGt(RST629)Byg |
| Gene/Transgene symbol | Sema3e |
Information from provider
| Provider | Roland Friedel |
| Provider affiliation | Soriano Lab, Department of Developomental & Regenerative Biology, Mount Sinai School of Medicine |
| Additional owner | Dr. Tessier-Lavigne, Genentech Inc, San Francisco CA, USA |
| Genetic information | The allele RST629 represents an insertion of a gene trap vector (pGT0TMpfs) into the fourth intron of the Semaphorin3E gene. The trap vector contains lacZ and PLAP reporters. Northern blotting has shown that the mutation completely disrupts the wildtype mRNA. |
| Phenotypic information | Homozygous mutants are viable and fertile. No gross abnormalities have been detected. |
| Breeding history | Backcrossed for 5 generations to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal motor neuron morphology / MGI
- abnormal motor neuron innervation pattern / MGI
- abnormal retina morphology / MGI
- abnormal somite development / MGI
- abnormal retinal vasculature morphology / MGI
- nervous system phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal intersomitic vessel morphology / MGI
- Bergmeister's papilla / MGI
Literature references
- Defining brain wiring patterns and mechanisms through gene trapping in mice.;Leighton P A, Mitchell K J, Goodrich L V, Lu X, Pinson K, Scherz P, Skarnes W C, Tessier-Lavigne M, ;2001;Nature;410;174-9; 11242070
- Functional analysis of secreted and transmembrane proteins critical to mouse development.;Mitchell K J, Pinson K I, Kelly O G, Brennan J, Zupicich J, Scherz P, Leighton P A, Goodrich L V, Lu X, Avery B J, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, Skarnes W C, ;2001;Nature genetics;28;241-9; 11431694
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