BR/ChapOrl[cc]
| Status | Available to order |
| EMMA ID | EM:02476 |
| Citation information | RRID:IMSR_EM:02476 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | BR/ChapOrl[cc] |
| Alternative name | BR |
| Strain type | Spontaneous |
| Allele/Transgene symbol | BR |
| Gene/Transgene symbol | BR |
Information from provider
| Provider | Georges CHAPOUTHIER |
| Provider affiliation | UMR CNRS 7593 |
| Genetic information | Resistant to seizures induced by methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the benzodiazepine site, plus coat color black. Mendelian selection on sensitivity to 4 mg/kg i. p. of convulsant beta-CCM from a pool of four beta-CCM-sensitive strains (BALB/cBy, CBA/H, C3H/HeJ, DBA/2J) and four relatively resistant strains (C57BL/6J, C57BL/10J, XLII, NZB/B1NJ). Partially inbred and selected also for "black" coat color (for identification). |
| Phenotypic information | Resistant to seizures induced by methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the benzodiazepine site. |
| Breeding history | Partially inbred and selected also for "black" coat color (for identification). |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous (EM:02476, EM:02477 backg., a pool of 8 different strains, see Genetic Info.) males, homozygous (EM:02476, EM:02477 backg., a pool of 8 different strains, see Genetic Info.) females |
| Breeding at archiving centre | Mendelian selection on sensitivity to 4 mg/kg i. p. of convulsant beta-CCM from a pool of four beta-CCM-sensitive strains (BALB/cBy, CBA/H, C3H/HeJ, DBA/2J) and four relatively resistant strains (C57BL/6J, C57BL/10J, XLII, NZB/B1NJ). Partially inbred and selected also for colour "black" (for identification). |
| Stage of embryos | 2-cell |
Literature references
- Genetic selection of mouse lines differing in sensitivity to a benzodiazepine receptor inverse agonist.;Chapouthier G, Launay J M, Venault P, Breton C, Roubertoux P L, Crusio W E, ;1998;Brain research;787;85-90; 9518562
- Mice selected for differences in sensitivity to a benzodiazepine receptor inverse agonist vary in intermale aggression.;Guillot P V, Sluyter F, Crusio W E, Chapouthier G, ;1999;Neurogenetics;2;171-5; 10541591
- Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands.;Rinaldi D, Boutrel B, Adrien J, Venault P, Chapouthier G, ;2000;Behavior genetics;30;277-84; 11206082
- Divergent levels of anxiety in mice selected for differences in sensitivity to a convulsant agent.;Suaudeau C, Rinaldi D, Lepicard E, Venault P, Crusio W E, Costentin J, Chapouthier G, ;2000;Physiology & behavior;71;517-23; 11239670
- Mouse lines differing in sensitivity to beta-CCM differ in tasks used for testing antidepressants.;Do-Rego Jean-Claude, Suaudeau Charles, Chapouthier Georges, Costentin Jean, ;2002;Pharmacology, biochemistry, and behavior;72;411-6; 11900813
- Mouse lines selected for difference in sensitivity to beta-CCM also differ in memory processes.;Venault Patrice, Beracochea Daniel, Valleau Magalie, Joubert Chantal, Chapouthier Georges, ;2006;Behavioural brain research;173;282-7; 16887204