CBA.Cg-Tg(Ins1-Frk-Y504F)1Ubc/Kieg
| Status | Available to order |
| EMMA ID | EM:00248 |
| Citation information | RRID:IMSR_EM:00248 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CBA.Cg-Tg(Ins1-Frk-Y504F)1Ubc/Kieg |
| Alternative name | RIP-GTK |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Ins1-Frk-Y504F)1Ubc |
| Gene/Transgene symbol | Tg(Ins1-Frk-Y504F)1Ubc |
Information from provider
| Provider | Michael Welsh |
| Provider affiliation | Dept of Medical Cell Biology,, Uppsala University |
| Phenotypic information | Increased pancreas, beta-cell mass and increased beta-cell cytotoxicity in response to stress (streptocin and cytokines). |
| References |
|
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Literature references
- Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK.;Annerén C, Welsh M, ;2001;Molecular medicine (Cambridge, Mass.);7;301-10; 11474576
- GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.;Annerén Cecilia, Welsh Michael, ;2002;Molecular medicine (Cambridge, Mass.);8;705-13; 12520087
- Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin.;Annerén C, ;2002;The Journal of endocrinology;172;145-53; 11786382