MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
B6;129S6-Rr4tm1Hgc/H
| Status | Available to order |
| EMMA ID | EM:02481 |
| Citation information | RRID:IMSR_EM:02481 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S6-Rr4tm1Hgc/H |
| Alternative name | uc482 knockout |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rr4tm1Hgc |
| Gene/Transgene symbol | Rr4 |
Information from provider
| Provider | Rajesh Thakker |
| Provider affiliation | Nuffield Department of Clinical Medicine, University of Oxford |
| Additional owner | Received as an unrestricted gift by Dr Nadav Ahituv. |
| Genetic information | An ultra-conserved non-coding element, regulatory region 4 (uc482), has been genetically knocked out in the mouse line uc482KO. This element is located approximately 400 kb downstream of the Sox3 gene. |
| Phenotypic information | To date this mouse strain does not have an overt phenotype. |
| Breeding history | Line was rederived from 129S6 ES cells. Blastocysts were introduced into C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6J males |
| Breeding at archiving centre | Mice were backcrossed to C57BL/6J, and heterozygous males provided for sperm freezing. |
Disease and phenotype information
Literature references
- Deletion of ultraconserved elements yields viable mice.;Ahituv Nadav, Zhu Yiwen, Visel Axel, Holt Amy, Afzal Veena, Pennacchio Len A, Rubin Edward M, ;2007;PLoS biology;5;e234; 17803355