MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
STOCK Tg(Prnp-SMN)92Ahmb/H
| Status | Available to order |
| EMMA ID | EM:02501 |
| Citation information | RRID:IMSR_EM:02501 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(Prnp-SMN)92Ahmb/H |
| Alternative name | PrP : fl-SMN |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-SMN)92Ahmb |
| Gene/Transgene symbol | Tg(Prnp-SMN)92Ahmb |
Information from provider
| Provider | Nicholas Parkinson |
| Provider affiliation | University of Oxford |
| Additional owner | Prof. Arthur Burghes, The Ohio State University, Columbus OH, USA |
| Genetic information | Full length human SMN transgene behind PrP promoter, as developed by Arthur Burghes. |
| Phenotypic information | These mice are aphenotypic. |
| Breeding history | This transgene was originally maintained on the SMN2-low background (see paper). We have outcrossed these animals to FVB to segregate the PrP:Fl-SMN transgene away from other transgenes and knockout alleles. These animals have been maintained on an FVB/N background for two generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous FVB males |
| Breeding at archiving centre | None. Males were archived at the time of arrival at the archiving centre. |
Disease and phenotype information
Literature references
- Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect.;Gavrilina Tatiana O, McGovern Vicki L, Workman Eileen, Crawford Thomas O, Gogliotti Rocky G, DiDonato Christine J, Monani Umrao R, Morris Glenn E, Burghes Arthur H M, ;2008;Human molecular genetics;17;1063-75; 18178576