FVB.Cg-Tg(CAG-HSPB1)LPks/H
| Status | Available to order |
| EMMA ID | EM:02503 |
| Citation information | RRID:IMSR_EM:02503 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB.Cg-Tg(CAG-HSPB1)LPks/H |
| Alternative name | HSP27 WT Low copy line |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CAG-HSPB1)LPks |
| Gene/Transgene symbol | Tg(CAG-HSPB1)LPks |
Information from provider
| Provider | Nicholas Parkinson |
| Provider affiliation | University of Oxford |
| Genetic information | This line contains a transgenic construct for human HSP27 wild-type coding sequence behind the chicken actin pCAGGS promoter. This line is low copy number with approximately 25 copies of the transgene in heterozygous mice. |
| Phenotypic information | No phenotype in transgenic carries. |
| Breeding history | After founder animals were identified for this transgene they have been consistently backcrossed to FVB animals. This line represents a stable insertion number of approximately 25 and has been backcrossed to N5. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.;Evgrafov Oleg V, Mersiyanova Irena, Irobi Joy, Van Den Bosch Ludo, Dierick Ines, Leung Conrad L, Schagina Olga, Verpoorten Nathalie, Van Impe Katrien, Fedotov Valeriy, Dadali Elena, Auer-Grumbach Michaela, Windpassinger Christian, Wagner Klaus, Mitrovic Zoran, Hilton-Jones David, Talbot Kevin, Martin Jean-Jacques, Vasserman Natalia, Tverskaya Svetlana, Polyakov Alexander, Liem Ronald K H, Gettemans Jan, Robberecht Wim, De Jonghe Peter, Timmerman Vincent, ;2004;Nature genetics;36;602-6; 15122254