STOCK Smad2tm6(SMAD2)Rob/H

Status

Available to order

EMMA IDEM:02511
Citation informationRRID:IMSR_EM:02511 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Smad2tm6(SMAD2)Rob/H
Alternative nameSmad2 SF
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolSmad2tm6(SMAD2)Rob
Gene/Transgene symbolSmad2

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Genetic informationKnock-in allele at exon 1 of the Smad2 locus of an epitope-tagged (FLAG) human cDNA encoding short isoform of Smad2. Of use in evaluating Smad2-interacting partners in vivo and studies of TGFb signalling in vivo.
Phenotypic informationHomozygous lethal at 8.5 dpc.
Breeding historyBackcrossed to 129/SvEv
ReferencesNone available
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • absent mandible / MGI
  • abnormal heart development / MGI
  • abnormal heart tube morphology / MGI
  • abnormal craniofacial morphology / MGI
  • microcephaly / MGI
  • abnormal mandible morphology / MGI
  • mandible hypoplasia / MGI
  • exencephaly / MGI
  • absent notochord / MGI
  • abnormal eye development / MGI
  • absent mesoderm / MGI
  • failure of primitive streak formation / MGI
  • failure to gastrulate / MGI
  • decreased embryo size / MGI
  • abnormal proximal-distal axis patterning / MGI
  • abnormal extraembryonic endoderm formation / MGI
  • embryonic growth arrest / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal eye morphology / MGI
  • no abnormal phenotype detected / MGI
  • absent extraembryonic ectoderm / MGI
  • abnormal chorion morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal egg cylinder morphology / MGI
  • absent allantois / MGI
  • abnormal forebrain development / MGI
  • abnormal embryonic epiblast morphology / MGI
  • abnormal embryonic-extraembryonic boundary morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal dorsal aorta morphology / MGI
  • absent amnion / MGI
  • abnormal ectoplacental cone morphology / MGI
  • holoprosencephaly / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • abnormal Meckel's cartilage morphology / MGI
  • abnormal hindbrain development / MGI
  • embryonic lethality during organogenesis / MGI
  • absent primitive node / MGI
  • absent chorion / MGI
  • failure of chorioallantoic fusion / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • abnormal visceral endoderm morphology / MGI
  • abnormal proamniotic cavity morphology / MGI
  • absent foregut / MGI
  • rostral body truncation / MGI
  • absent optic placodes / MGI
  • abnormal primitive streak elongation / MGI
  • absent head fold / MGI
  • absent endoderm / MGI
  • absent ectoderm / MGI

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  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
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