IMPC phenotypes (gene matching)
STOCK Lhx1tm1Bhr/H
| Status | Available to order |
| EMMA ID | EM:02519 |
| Citation information | RRID:IMSR_EM:02519 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Lhx1tm1Bhr/H |
| Alternative name | Lim-1 (Lhx-1) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lhx1tm1Bhr |
| Gene/Transgene symbol | Lhx1 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | Loss of function mutation at the Lhx1 (Lim-1) locus. Coding sequence replaced by neo expression vector. Mutation is useful for studying gastrulation of the mouse embryo and specification of the definitive endoderm. |
| Phenotypic information | Homozygous lethal at day 10 of gestation. |
| Breeding history | Outcrossed to CD1. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
- absent kidney / MGI
- abnormal brain development / MGI
- abnormal spinal cord morphology / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- abnormal allantois morphology / MGI
- abnormal gastrulation movements / MGI
- abnormal egg cylinder morphology / MGI
- absent ovary / MGI
- abnormal primitive node morphology / MGI
- dilated allantois / MGI
- small allantois / MGI
- agonadal / MGI
- abnormal hindbrain development / MGI
- absent testes / MGI
- acephaly / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- absent midbrain / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- rostral-caudal axis duplication / MGI
- absent prechordal mesoderm / MGI
- abnormal anterior head development / MGI
- abnormal primitive streak formation / MGI
- abnormal rostral-caudal axis patterning / MGI
- abnormal primitive streak elongation / MGI
- abnormal female reproductive system morphology / MGI
- abnormal male reproductive system morphology / MGI
- absent ureter / MGI
- absent metanephros / MGI
MGI phenotypes (gene matching)
- absent kidney / MGI
- abnormal brain development / MGI
- abnormal spinal cord morphology / MGI
- abnormal female reproductive system morphology / MGI
- abnormal male reproductive system morphology / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- abnormal allantois morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal gastrulation movements / MGI
- abnormal primitive streak formation / MGI
- no phenotypic analysis / MGI
- abnormal egg cylinder morphology / MGI
- absent ovary / MGI
- absent ureter / MGI
- abnormal primitive node morphology / MGI
- dilated allantois / MGI
- small allantois / MGI
- abnormal rostral-caudal axis patterning / MGI
- agonadal / MGI
- abnormal hindbrain development / MGI
- absent testes / MGI
- acephaly / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- absent metanephros / MGI
- absent midbrain / MGI
- embryonic-extraembryonic boundary constriction / MGI
- absent forebrain / MGI
- rostral-caudal axis duplication / MGI
- absent prechordal mesoderm / MGI
- abnormal primitive streak elongation / MGI
- abnormal anterior head development / MGI
Literature references
- Requirement for Lim1 in head-organizer function.;Shawlot W, Behringer R R, ;1995;Nature;374;425-30; 7700351