- decreased leukocyte cell number / MGI
- abnormal erythropoiesis / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- increased mean corpuscular volume / MGI
- decreased erythrocyte cell number / MGI
- increased erythroid progenitor cell number / MGI
- decreased lymphocyte cell number / MGI
- increased mean corpuscular hemoglobin / MGI
- increased red blood cell distribution width / MGI
129S/SvEv-Klf13tm1Coll/CollH
| Status | Available to order |
| EMMA ID | EM:02522 |
| Citation information | RRID:IMSR_EM:02522 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S/SvEv-Klf13tm1Coll/CollH |
| Alternative name | KLF13-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Klf13tm1Coll |
| Gene/Transgene symbol | Klf13 |
Information from provider
| Provider | Paul Kemp |
| Provider affiliation | Imperial College |
| Genetic information | The first intron, encoding the transactivation domain and the first of the protein's three zinc fingers, has been replaced with a neomycin resistance cassette. |
| Phenotypic information | Mice show altered T, B cell and erythroblast differentiation |
| Breeding history | Inbred |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous males |
| Breeding at archiving centre | Males were archived by sperm freezing on arrival. No breeding was performed at the archiving centre. Presumed homozygous. |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- decreased leukocyte cell number / MGI
- abnormal erythropoiesis / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- thymus hyperplasia / MGI
- increased thymocyte number / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- increased mean corpuscular volume / MGI
- abnormal immune system organ morphology / MGI
- decreased erythrocyte cell number / MGI
- increased erythroid progenitor cell number / MGI
- decreased lymphocyte cell number / MGI
- increased double-positive T cell number / MGI
- increased mean corpuscular hemoglobin / MGI
- abnormal T cell number / MGI
- increased splenocyte number / MGI
- decreased splenocyte apoptosis / MGI
- decreased thymocyte apoptosis / MGI
- increased red blood cell distribution width / MGI
Literature references
- KLF13 influences multiple stages of both B and T cell development.;Outram Susan V, Gordon Adele R, Hager-Theodorides Ariadne L, Metcalfe James, Crompton Tessa, Kemp Paul, ;2008;Cell cycle (Georgetown, Tex.);7;2047-55; 18604172
- Splenomegaly and modified erythropoiesis in KLF13-/- mice.;Gordon Adele R, Outram Susan V, Keramatipour Mohammad, Goddard Catherine A, Colledge William H, Metcalfe James C, Hager-Theodorides Ariadne L, Crompton Tessa, Kemp Paul R, ;2008;The Journal of biological chemistry;283;11897-904; 18285334
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