129S/SvEv-Klf13tm1Coll/CollH

Status

Available to order

EMMA IDEM:02522
Citation informationRRID:IMSR_EM:02522 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain name129S/SvEv-Klf13tm1Coll/CollH
Alternative nameKLF13-/-
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolKlf13tm1Coll
Gene/Transgene symbolKlf13

Information from provider

ProviderPaul Kemp
Provider affiliationImperial College
Genetic informationThe first intron, encoding the transactivation domain and the first of the protein's three zinc fingers, has been replaced with a neomycin resistance cassette.
Phenotypic informationMice show altered T, B cell and erythroblast differentiation
Breeding historyInbred
References
  • KLF13 influences multiple stages of both B and T cell development.;Outram Susan V, Gordon Adele R, Hager-Theodorides Ariadne L, Metcalfe James, Crompton Tessa, Kemp Paul, ;2008;Cell cycle (Georgetown, Tex.);7;2047-55; 18604172
  • Splenomegaly and modified erythropoiesis in KLF13-/- mice.;Gordon Adele R, Outram Susan V, Keramatipour Mohammad, Goddard Catherine A, Colledge William H, Metcalfe James C, Hager-Theodorides Ariadne L, Crompton Tessa, Kemp Paul R, ;2008;The Journal of biological chemistry;283;11897-904; 18285334
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous males
Breeding at archiving centreMales were archived by sperm freezing on arrival. No breeding was performed at the archiving centre. Presumed homozygous.

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased leukocyte cell number / MGI
  • abnormal erythropoiesis / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • increased mean corpuscular volume / MGI
  • decreased erythrocyte cell number / MGI
  • increased erythroid progenitor cell number / MGI
  • decreased lymphocyte cell number / MGI
  • increased mean corpuscular hemoglobin / MGI
  • increased red blood cell distribution width / MGI
MGI phenotypes (gene matching)
  • decreased leukocyte cell number / MGI
  • abnormal erythropoiesis / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • thymus hyperplasia / MGI
  • increased thymocyte number / MGI
  • decreased thymocyte number / MGI
  • abnormal immune system cell morphology / MGI
  • increased mean corpuscular volume / MGI
  • abnormal immune system organ morphology / MGI
  • decreased erythrocyte cell number / MGI
  • increased erythroid progenitor cell number / MGI
  • decreased lymphocyte cell number / MGI
  • increased double-positive T cell number / MGI
  • increased mean corpuscular hemoglobin / MGI
  • abnormal T cell number / MGI
  • increased splenocyte number / MGI
  • decreased splenocyte apoptosis / MGI
  • decreased thymocyte apoptosis / MGI
  • increased red blood cell distribution width / MGI

Literature references

  • KLF13 influences multiple stages of both B and T cell development.;Outram Susan V, Gordon Adele R, Hager-Theodorides Ariadne L, Metcalfe James, Crompton Tessa, Kemp Paul, ;2008;Cell cycle (Georgetown, Tex.);7;2047-55; 18604172
  • Splenomegaly and modified erythropoiesis in KLF13-/- mice.;Gordon Adele R, Outram Susan V, Keramatipour Mohammad, Goddard Catherine A, Colledge William H, Metcalfe James C, Hager-Theodorides Ariadne L, Crompton Tessa, Kemp Paul R, ;2008;The Journal of biological chemistry;283;11897-904; 18285334

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).