129S(Cg)-Foxh1^tm1Jlw/H

Status	Available to order
EMMA ID	EM:02525
Citation information	RRID:IMSR_EM:02525 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	129S(Cg)-Foxh1^tm1Jlw/H
Alternative name	FoxH1 (FAST)
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Foxh1^tm1Jlw
Gene/Transgene symbol	Foxh1

Information from provider

Provider	Elizabeth Robertson
Provider affiliation	Sir William Dunn School of Pathology, University of Oxford
Additional owner	For further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk
Genetic information	Coding sequence of Foxh1 replaced by neo expression cassette causing a loss of function at the Foxh1 locus.
Phenotypic information	Homozygous lethal at day 8 of gestation.
Breeding history	Backcrossed to 129/SvEv.
References	FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.;Hoodless P A, Pye M, Chazaud C, Labbé E, Attisano L, Rossant J, Wrana J L, ;2001;Genes & development;15;1257-71; 11358869
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Alobar holoprosencephaly / Orphanet_93925
Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
Microform holoprosencephaly / Orphanet_280200
Septopreoptic holoprosencephaly / Orphanet_280195
Semilobar holoprosencephaly / Orphanet_220386
Lobar holoprosencephaly / Orphanet_93924

MGI phenotypes (allele matching)

abnormal heart development / MGI
abnormal heart looping / MGI
trabecula carnea hypoplasia / MGI
absent notochord / MGI
decreased embryo size / MGI
pericardial edema / MGI
disorganized myocardium / MGI
abnormal pharyngeal arch artery morphology / MGI
absent heart right ventricle / MGI
abnormal heart left ventricle morphology / MGI
embryonic growth retardation / MGI
failure of heart looping / MGI
holoprosencephaly / MGI
abnormal heart ventricle morphology / MGI
abnormal neural plate morphology / MGI
abnormal cardiac outflow tract development / MGI
abnormal mesendoderm development / MGI
absent primitive node / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
fused somites / MGI
embryonic-extraembryonic boundary constriction / MGI
absent neural folds / MGI
absent prechordal mesoderm / MGI
abnormal pericardial cavity morphology / MGI
abnormal anterior primitive streak morphology / MGI
abnormal anterior head development / MGI

MGI phenotypes (gene matching)

lowered ear position / MGI
absent mandible / MGI
abnormal sternum morphology / MGI
abnormal heart development / MGI
abnormal heart looping / MGI
trabecula carnea hypoplasia / MGI
microcephaly / MGI
abnormal cranium morphology / MGI
abnormal intestine morphology / MGI
right pulmonary isomerism / MGI
dextrocardia / MGI
mesocardia / MGI
absent spleen / MGI
absent notochord / MGI
anophthalmia / MGI
decreased embryo size / MGI
pericardial edema / MGI
thymus hypoplasia / MGI
anencephaly / MGI
no abnormal phenotype detected / MGI
disorganized myocardium / MGI
abnormal pharyngeal arch artery morphology / MGI
no phenotypic analysis / MGI
acrania / MGI
absent pericardium / MGI
absent heart right ventricle / MGI
abnormal heart left ventricle morphology / MGI
diaphragmatic hernia / MGI
embryonic growth retardation / MGI
abnormal aortic arch morphology / MGI
heterotaxia / MGI
right aortic arch / MGI
failure of heart looping / MGI
abnormal thoracic cavity morphology / MGI
holoprosencephaly / MGI
cyclopia / MGI
abnormal heart ventricle morphology / MGI
abnormal neural plate morphology / MGI
abnormal inferior vena cava morphology / MGI
abnormal cardiac outflow tract development / MGI
proboscis / MGI
abnormal mesendoderm development / MGI
absent primitive node / MGI
microstomia / MGI
common atrium / MGI
common ventricle / MGI
heart left ventricle hypoplasia / MGI
vascular ring / MGI
abnormal right subclavian artery morphology / MGI
right-sided stomach / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
abdominal situs ambiguus / MGI
situs inversus with levocardia / MGI
double outlet right ventricle with atrioventricular septal defect / MGI
double outlet right ventricle, Taussig bing type / MGI
fused somites / MGI
embryonic-extraembryonic boundary constriction / MGI
absent neural folds / MGI
absent prechordal mesoderm / MGI
abnormal pericardial cavity morphology / MGI
abnormal anterior primitive streak morphology / MGI
abnormal anterior head development / MGI

Literature references

FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.;Hoodless P A, Pye M, Chazaud C, Labbé E, Attisano L, Rossant J, Wrana J L, ;2001;Genes & development;15;1257-71; 11358869

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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129S(Cg)-Foxh1tm1Jlw/H