129-Foxa2tm1Jrt/H

Status

Available to order

EMMA IDEM:02526
Citation informationRRID:IMSR_EM:02526 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain name129-Foxa2tm1Jrt/H
Alternative nameHNF3beta (Foxa2)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFoxa2tm1Jrt
Gene/Transgene symbolFoxa2

Information from provider

ProviderElizabeth Robertson
Provider affiliationSir William Dunn School of Pathology, University of Oxford
Genetic informationCoding sequence of Foxa2 replaced by neo expression construct, causing a loss of function at the Foxa2 locus. Can be used to study Foxa2 function during gastrulation.
Phenotypic informationHomozygous lethal at day 8 of gestation.
Breeding historyBackcrossed to 129/SvEv.
References
  • FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.;Hoodless P A, Pye M, Chazaud C, Labbé E, Attisano L, Rossant J, Wrana J L, ;2001;Genes & development;15;1257-71; 11358869
  • HNF-3 beta is essential for node and notochord formation in mouse development.;Ang S L, Rossant J, ;1994;Cell;78;561-74; 8069909
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • malocclusion / MGI
  • decreased body size / MGI
  • circling / MGI
  • hunched posture / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • long incisors / MGI
  • absent mesoderm / MGI
  • increased embryonic tissue cell apoptosis / MGI
  • abnormal primitive streak formation / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • absent primitive node / MGI
  • abnormal primitive streak elongation / MGI
  • abnormal foregut morphology / MGI
  • absent floor plate / MGI
  • absent notochord / MGI
  • abnormal somite shape / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal neural tube morphology / MGI
  • kinked neural tube / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal primitive endoderm morphology / MGI
  • decreased somite size / MGI
  • fused somites / MGI
  • embryonic-extraembryonic boundary constriction / MGI
  • rostral body truncation / MGI
MGI phenotypes (gene matching)
  • malocclusion / MGI
  • abnormal cell death / MGI
  • abnormal foregut morphology / MGI
  • absent floor plate / MGI
  • absent notochord / MGI
  • decreased body size / MGI
  • abnormal eye development / MGI
  • circling / MGI
  • abnormal gait / MGI
  • hunched posture / MGI
  • impaired righting response / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • absent mesoderm / MGI
  • abnormal endoderm development / MGI
  • abnormal somite development / MGI
  • abnormal somite shape / MGI
  • decreased embryo size / MGI
  • reduced female fertility / MGI
  • abnormal glucose homeostasis / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primitive streak formation / MGI
  • kinked neural tube / MGI
  • abnormal nervous system development / MGI
  • abnormal craniofacial development / MGI
  • abnormal miscarriage rate / MGI
  • long incisors / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • abnormal metabolism / MGI
  • abnormal paraxial mesoderm morphology / MGI
  • absent estrous cycle / MGI
  • absent estrus / MGI
  • absent primitive node / MGI
  • increased liver triglyceride level / MGI
  • abnormal neuron differentiation / MGI
  • mortality/aging / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal primitive endoderm morphology / MGI
  • decreased somite size / MGI
  • fused somites / MGI
  • delayed heart development / MGI
  • embryonic-extraembryonic boundary constriction / MGI
  • rostral body truncation / MGI
  • abnormal chordamesoderm morphology / MGI
  • abnormal primitive streak elongation / MGI
  • increased embryonic tissue cell apoptosis / MGI

Literature references

  • FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.;Hoodless P A, Pye M, Chazaud C, Labbé E, Attisano L, Rossant J, Wrana J L, ;2001;Genes & development;15;1257-71; 11358869
  • HNF-3 beta is essential for node and notochord formation in mouse development.;Ang S L, Rossant J, ;1994;Cell;78;561-74; 8069909
  • Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance.;Mansour Abed AlFatah, Khazanov-Zisman Sophie, Netser Yaara, Klar Avihu, Ben-Arie Nissim, ;2014;Development (Cambridge, England);141;574-84; 24401371

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
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