STOCK Tg(Prnp-PRNP*6OR)K6M6Pcg/H
| Status | Available to order |
| EMMA ID | EM:02538 |
| Citation information | RRID:IMSR_EM:02538 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(Prnp-PRNP*6OR)K6M6Pcg/H |
| Alternative name | Tg(KuPrP)K6M6 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Prnp-PRNP*6OR)K6M6Pcg |
| Gene/Transgene symbol | Tg(Prnp-PRNP*6OR)K6M6Pcg |
Information from provider
| Provider | Peter Griffiths |
| Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
| Genetic information | Tg(KuPrP)K6M6 mice were generated using a ~12 kb transgene, based on the pPrPHG plasmid containing kudu Prnp open reading frame sequence, which was microinjected into pronuclear stage FVB/NIco fertilised oocytes. |
| Phenotypic information | Overexpression of transgenic kudu PRNP (PrPC) protein in brain and other tissues, in order to confer increased susceptibility to TSE diseases, including BSE, compared to wild-type mice. |
| Breeding history | Inbred to 4 generations. Brother and sister matings. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |