C3HeB/FeJ-Csf1Mhdabap25/Ieg

Status

Available to order

EMMA IDEM:02555
Citation informationRRID:IMSR_EM:02555 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3HeB/FeJ-Csf1Mhdabap25/Ieg
Alternative nameBAP025
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCsf1Mhdabap25
Gene/Transgene symbolCsf1

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationMutation in the Csf1 gene: c. 127T>A, p. Ile43Phe
Phenotypic informationalkaline phosphatase low
Breeding historymore than 2 times backcrossed to C3HeB/FeJ
References
  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
  • Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C3H males

Disease and phenotype information

MGI phenotypes (gene matching)
  • fragile skeleton / MGI
  • abnormal bone marrow cavity morphology / MGI
  • osteoporosis / MGI
  • osteopetrosis / MGI
  • abnormal parietal bone morphology / MGI
  • failure of tooth eruption / MGI
  • absent incisors / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal long bone hypertrophic chondrocyte zone / MGI
  • decreased circulating phosphate level / MGI
  • decreased leukocyte cell number / MGI
  • decreased monocyte cell number / MGI
  • extramedullary hematopoiesis / MGI
  • increased granulocyte number / MGI
  • decreased bone marrow cell number / MGI
  • domed cranium / MGI
  • short limbs / MGI
  • abnormal tibia morphology / MGI
  • abnormal femur morphology / MGI
  • abnormal autopod morphology / MGI
  • short tail / MGI
  • abnormal mammary gland development / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • small spleen / MGI
  • thymus cortex hypoplasia / MGI
  • abnormal ovary morphology / MGI
  • abnormal ovarian folliculogenesis / MGI
  • decreased body weight / MGI
  • abnormal mating frequency / MGI
  • reduced male mating frequency / MGI
  • abnormal eating behavior / MGI
  • abnormal circulating calcium level / MGI
  • impaired embryo implantation / MGI
  • abnormal postnatal growth / MGI
  • postnatal growth retardation / MGI
  • abnormal lactation / MGI
  • reduced fertility / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • abnormal ovulation / MGI
  • decreased litter size / MGI
  • premature death / MGI
  • abnormal spleen red pulp morphology / MGI
  • abnormal bone marrow morphology / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal sperm number / MGI
  • decreased corpora lutea number / MGI
  • decreased mature ovarian follicle number / MGI
  • oligozoospermia / MGI
  • decreased circulating testosterone level / MGI
  • abnormal bone remodeling / MGI
  • no phenotypic analysis / MGI
  • amyloid beta deposits / MGI
  • decreased ovulation rate / MGI
  • impaired granulosa cell differentiation / MGI
  • increased width of hypertrophic chondrocyte zone / MGI
  • abnormal uterus development / MGI
  • abnormal bone structure / MGI
  • abnormal compact bone morphology / MGI
  • impaired macrophage chemotaxis / MGI
  • decreased macrophage cell number / MGI
  • abnormal masseter muscle morphology / MGI
  • decreased length of long bones / MGI
  • abnormal thyroid parafollicular C-cell morphology / MGI
  • abnormal auditory brainstem response / MGI
  • abnormal vestibular system physiology / MGI
  • abnormal hematopoietic stem cell morphology / MGI
  • increased testis weight / MGI
  • abnormal testis physiology / MGI
  • decreased spleen weight / MGI
  • abnormal osteoclast morphology / MGI
  • abnormal osteoclast cell number / MGI
  • decreased osteoclast cell number / MGI
  • abnormal osteoblast morphology / MGI
  • decreased bone resorption / MGI
  • abnormal osteoblast physiology / MGI
  • increased T cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased susceptibility to atherosclerosis / MGI
  • abnormal Langerhans cell physiology / MGI
  • behavior/neurological phenotype / MGI
  • osteosclerosis / MGI
  • abnormal skeleton morphology / MGI
  • increased bone mass / MGI
  • abnormal mammary gland growth during pregnancy / MGI
  • abnormal mammary gland growth during lactation / MGI
  • increased long bone epiphyseal plate size / MGI
  • abnormal Kupffer cell morphology / MGI
  • abnormal Langerhans cell morphology / MGI
  • absent Langerhans cell / MGI
  • abnormal perivascular macrophage morphology / MGI
  • abnormal myeloid leukocyte morphology / MGI
  • abnormal osteoclast differentiation / MGI
  • abnormal neurite morphology / MGI
  • slow postnatal weight gain / MGI
  • abnormal osteocyte morphology / MGI
  • abnormal splenic cell ratio / MGI
  • abnormal ovarian follicle number / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • prolonged estrous cycle / MGI
  • abnormal proestrus / MGI
  • myometrium hypoplasia / MGI
  • endometrium hypoplasia / MGI
  • necrospermia / MGI
  • abnormal splenocyte physiology / MGI
  • decreased trabecular bone thickness / MGI
  • abnormal mammary gland lobule morphology / MGI
  • abnormal mammary gland alveolus morphology / MGI
  • decreased fertilization frequency / MGI
  • decreased hippocampus pyramidal cell number / MGI
  • abnormal visual evoked potential / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone mass / MGI
  • increased trabecular bone volume / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • decreased secondary ovarian follicle number / MGI
  • abnormal tooth root development / MGI
  • impaired osteoblast differentiation / MGI
  • abnormal auditory brainstem response waveform shape / MGI
  • thymus medulla atrophy / MGI
  • decreased bone mineralization / MGI
  • round snout / MGI
  • abnormal dentin mineralization / MGI
  • increased osteocyte apoptosis / MGI
  • abnormal osteocyte lacuna morphology / MGI
  • abnormal osteocyte dendritic process morphology / MGI
  • abnormal dental follicle morphology / MGI
  • abnormal predentin morphology / MGI
  • absent teeth / MGI

Literature references

  • Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
  • Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017

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Practical information

Genotyping protocol

Example health report
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Legally binding conditions for the transfer

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