IMPC phenotypes (gene matching)
B6.129-Myh9tm1.1Gac/Orl
| Status | Available to order |
| EMMA ID | EM:02572 |
| Citation information | RRID:IMSR_EM:02572 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Myh9tm1.1Gac/Orl |
| Alternative name | B6.129 floxed Myh9 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Myh9tm1.1Gac |
| Gene/Transgene symbol | Myh9 |
Information from provider
| Provider | GACHET CHRISTIAN |
| Provider affiliation | U 311, EFS- ALSACE |
| Genetic information | Exon 1 of Myh9 gene was flanked by loxP sites by homologous recombination. This floxed allele was correctly expressed and allows conditional, tissue-specific gene deletion with the proper tissue-specific, cre recombinase-expressing mice. |
| Phenotypic information | Absence of non muscle cell contraction when inactivation of the gene is achieved through the crossing of Myh9 floxed mice with tissue-specific, cre recombinase-expressing mice. |
| Breeding history | Backcrossed 10 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- MYH9-related disease / Orphanet_182050
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
MGI phenotypes (gene matching)
- abnormal thrombopoiesis / MGI
- abnormal megakaryocyte differentiation / MGI
- abnormal cell morphology / MGI
- cataract / MGI
- increased incidence of corneal inflammation / MGI
- abnormal germ layer development / MGI
- failure to gastrulate / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta labyrinth morphology / MGI
- pale yolk sac / MGI
- no abnormal phenotype detected / MGI
- abnormal megakaryocyte morphology / MGI
- abnormal blood coagulation / MGI
- abnormal lens fiber morphology / MGI
- albuminuria / MGI
- no phenotypic analysis / MGI
- abnormal cell migration / MGI
- thrombocytopenia / MGI
- abnormal vascular branching morphogenesis / MGI
- abnormal vitelline vasculature morphology / MGI
- abnormal cell adhesion / MGI
- embryonic growth retardation / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- abnormal placenta size / MGI
- abnormal platelet morphology / MGI
- increased susceptibility to age-related hearing loss / MGI
- abnormal brain vasculature morphology / MGI
- abnormal neutrophil morphology / MGI
- hematuria / MGI
- abnormal eye physiology / MGI
- glomerulosclerosis / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- embryo phenotype / MGI
- vision/eye phenotype / MGI
- hematopoietic system phenotype / MGI
- corneal vascularization / MGI
- increased bleeding time / MGI
- impaired hearing / MGI
- podocyte foot process effacement / MGI
- increased megakaryocyte cell number / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- abnormal visceral endoderm morphology / MGI
- thin placenta labyrinth / MGI
- abnormal placenta intervillous maternal lacunae morphology / MGI
- abnormal placenta fetal blood space morphology / MGI
- increased or absent threshold for auditory brainstem response / MGI
Literature references
- Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.;Léon Catherine, Eckly Anita, Hechler Béatrice, Aleil Boris, Freund Monique, Ravanat Catherine, Jourdain Marie, Nonne Christelle, Weber Josiane, Tiedt Ralph, Gratacap Marie-Pierre, Severin Sonia, Cazenave Jean-Pierre, Lanza François, Skoda Radek, Gachet Christian, ;2007;Blood;110;3183-91; 17664350
- Cell influx and contractile actomyosin force drive mammary bud growth and invagination.;Trela Ewelina, Lan Qiang, Myllymäki Satu-Marja, Villeneuve Clémentine, Lindström Riitta, Kumar Vinod, Wickström Sara A, Mikkola Marja L, ;2021;The Journal of cell biology;220;; 34042944