MGI phenotypes (allele matching)
B6.129P2-Azgp1tm1.1Sbah/Orl
| Status | Available to order |
| EMMA ID | EM:02573 |
| Citation information | RRID:IMSR_EM:02573 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Azgp1tm1.1Sbah/Orl |
| Alternative name | ZAG (zinc alpha two glycoprotein) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Azgp1tm1.1Sbah |
| Gene/Transgene symbol | Azgp1 |
Information from provider
| Provider | BAHRAM seiamak |
| Provider affiliation | Institut d'Hématologie et d'Immunologie |
| Genetic information | Targeted knock-out mice for MHC class I gene Azgp1 (Zag). Domains alpha1 and alpha2 of Azgp1, encoded by exons 1 and 2, are replaced with a floxed PGKNeo cassette. A loxP site is left behind after cre recombinase excision. |
| Phenotypic information | Overweight, adipocyte dysfunction, altered lipolysis. |
| Breeding history | Backcrossed to C57BL/6 for 10 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6 males |
Disease and phenotype information
Literature references
- Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice.;Rolli Véronique, Radosavljevic Mirjana, Astier Valérie, Macquin Cécile, Castan-Laurell Isabelle, Visentin Virgile, Guigné Charlotte, Carpéné Christian, Valet Philippe, Gilfillan Susan, Bahram Seiamak, ;2007;FEBS letters;581;394-400; 17234189
- AZGP1 deficiency promotes angiogenesis in prostate cancer.;Wen Ru M, Qiu Zhengyuan, Marti G Edward W, Peterson Eric E, Marques Fernando Jose Garcia, Bermudez Abel, Wei Yi, Nolley Rosalie, Lam Nathan, Polasko Alex LaPat, Chiu Chun-Lung, Zhang Dalin, Cho Sanghee, Karageorgos Grigorios Marios, McDonough Elizabeth, Chadwick Chrystal, Ginty Fiona, Jung Kyeong Joo, Machiraju Raghu, Mallick Parag, Crowley Laura, Pollack Jonathan R, Zhao Hongjuan, Pitteri Sharon J, Brooks James D, ;2024;Journal of translational medicine;22;383; 38659028