- premature death / MGI
- belly spot / MGI
- kinked tail / MGI
- decreased body size / MGI
- increased mean corpuscular volume / MGI
- curly tail / MGI
- abnormal vertebral arch morphology / MGI
- decreased vertebrae number / MGI
- thin cerebral cortex / MGI
- abnormal spatial working memory / MGI
- enlarged brain ventricles / MGI
- abnormal hindbrain morphology / MGI
- decreased neural crest cell number / MGI
C3H;C-Rps7Mtu/H
| Status | Available to order |
| EMMA ID | EM:02585 |
| Citation information | RRID:IMSR_EM:02585 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3H;C-Rps7Mtu/H |
| Alternative name | Montu |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Rps7Mtu |
| Gene/Transgene symbol | Rps7 |
Information from provider
| Provider | Debora Bogani |
| Provider affiliation | Mammalian Genetics Unit, MRC Harwell |
| Genetic information | Mutation maps to chromosome 12, proximal of D12Mit239. |
| Phenotypic information | Heterozygotes exhibit abnormal tail morphology, are deaf and have belly spots that are characteristic of neural crest defects. Homozygotes, do not appear to be viable, as they have an open neural tube. |
| Breeding history | Backcrossed to C3H/HeH. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Blackfan-Diamond anemia / Orphanet_124
MGI phenotypes (allele matching)
Literature references
- New semidominant mutations that affect mouse development.;Bogani Debora, Warr Nick, Elms Paul, Davies Jennifer, Tymowska-Lalanne Zuzanna, Goldsworthy Michelle, Cox Roger D, Keays David A, Flint Jonathan, Wilson Valerie, Nolan Pat, Arkell Ruth, ;2004;Genesis (New York, N.Y. : 2000);40;109-117; 15384171
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).
