STOCK EpoTg(TAg/Epo)134.3LCPjr/H

Status

Available to order

EMMA IDEM:02595
Citation informationRRID:IMSR_EM:02595 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK EpoTg(TAg/Epo)134.3LCPjr/H
Alternative nameEpo
Strain typeTransgenic Strains
Allele/Transgene symbolEpoTg(TAg/Epo)134.3LCPjr
Gene/Transgene symbolEpo

Information from provider

ProviderPatrick Maxwell
Provider affiliationWellcome Trust Centre for Human Genetics, University of Oxford
Genetic informationpBS construct with 16.5 kb of mouse Epo, including the entire Epo gene. A 2.7 kb Bgl1/BamH1 fragment of Sv40 DNA encoding "T" antigen was inserted into the 5'-UTR of the Epo gene.
Phenotypic informationThe insertion of SV40 T antigen sequence in the 5'-UTR of the native Epo gene results in very little Epo production from the fusion gene. Homozygotes have incomplete Epo deficiency and are anaemic. The mice express SV40 T antigen in a regulated fashion (by anaemia and hypoxia) in Epo-producing cells.
Breeding historyOutcrossed to C57BL/6J.
References
  • Identification of the renal erythropoietin-producing cells using transgenic mice.;Maxwell P H, Osmond M K, Pugh C W, Heryet A, Nicholls L G, Tan C C, Doe B G, Ferguson D J, Johnson M H, Ratcliffe P J, ;1993;Kidney international;44;1149-62; 8264149
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal erythropoiesis / MGI
  • abnormal heart development / MGI
  • ventricular hypoplasia / MGI
  • abnormal interventricular septum morphology / MGI
  • abnormal liver morphology / MGI
  • small liver / MGI
  • pale liver / MGI
  • abnormal liver physiology / MGI
  • anemia / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal placenta morphology / MGI
  • edema / MGI
  • pericardial edema / MGI
  • no abnormal phenotype detected / MGI
  • hyperoxia / MGI
  • hyperventilation / MGI
  • increased heart weight / MGI
  • thick ventricular wall / MGI
  • abnormal epicardium morphology / MGI
  • increased erythroid progenitor cell number / MGI
  • pallor / MGI
  • increased hepatocyte apoptosis / MGI
  • increased heart right ventricle weight / MGI
  • increased left ventricle weight / MGI
  • abnormal interventricular groove morphology / MGI
  • abnormal myocardial fiber physiology / MGI
  • enlarged myocardial fiber / MGI
  • increased spleen weight / MGI
  • hypoxia / MGI
  • decreased oxygen consumption / MGI
  • increased pulmonary ventilation / MGI
  • decreased angiogenesis / MGI
  • hemosiderosis / MGI
  • mortality/aging / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • decreased fetal derived definitive erythrocyte cell number / MGI

Literature references

  • Identification of the renal erythropoietin-producing cells using transgenic mice.;Maxwell P H, Osmond M K, Pugh C W, Heryet A, Nicholls L G, Tan C C, Doe B G, Ferguson D J, Johnson M H, Ratcliffe P J, ;1993;Kidney international;44;1149-62; 8264149

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

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